Vol 89, No 1 (2017)
- Year: 2017
- Published: 15.01.2017
- Articles: 22
- URL: https://ter-arkhiv.ru/0040-3660/issue/view/1820
Editorial
Mortality and risk factors for non-communicable diseases in Russia: Specific features, trends, and prognosis
Abstract
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Association of the polymorphic marker Glu23Lys in the KCNJ11 gene with hypertension in Kyrgyz patients
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Risk of death from circulatory diseases in a cohort of patients exposed to chronic radiation
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Associations between high levels of hostility and coronary heart disease in an open urban population among 25—64-year-old men
Abstract
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The effect of the level of total sodium deposited in the myocardium on its stiffness
Abstract
Aim. To determine a relationship between the level of total sodium in the myocardium to its stiffness. Subjects and methods. The investigation enrolled 18 hypertensive patients who had suddenly died; their mean age was 40±10 years; mean waist circumference, 102±12.5 cm; height, 170±7.7 cm; myocardial mass, 319±53 g. Results. The variation in the myocardial level of total sodium averaged 211.7±37.5 (min, 71.5; max, 226.17) mmol/l. The sodium level was ascertained to be affected to the greatest extent by myocardial mass (SS=3615.56; p=0.00029) and age at death (SS=1965.568; p=0.0029), whereas gender and smoking had a considerably lower impact (SS=778.584; p=0.03). A univariate regression analysis showed that there was a relationship between myocardial sodium levels and the thickness of the anterior wall of the left ventricle (β=0.94; p=0.000001; r2=0.88), that of the anterior wall of the right ventricle (β=0.82; p=0.000021; r2=0.66), and that of the interventricular septum (β=0.94; p=0.000001; r2=0.89). The wall thickness of the myocardium was established to depend on its sodium level (SS=21813.89; p=0.000001; r2=0.88): the higher sodium amount in the myocardium, the thicker its walls. The average velocity of acoustic wave propagation was 6.24±0.51 m/sec. A significant correlation was observed between sodium concentrations in the myocardium and its stiffness (β=0.72; p=0.00062; r2=0.49). Conclusion. The level of sodium deposited in the myocardium, which is directly related to dietary sodium intake, is significantly correlated with myocardial stiffness. It can be assumed that the elevated level of sodium deposited in the myocardium is an independent factor that changes the stiffness of the myocardium and appears to influence the development of its diastolic dysfunction.
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Light-chain deposition disease is a hematologic problem
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Numbers of early CD34+ progenitors of bone marrow hematopoiesis in patients with diffuse large B-cell lymphoma
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Clinical features of «metabolism» diseases of the skin in patients with chronic diffuse liver diseases
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Specific features of joint ultrasound study in patients with rheumatoid arthritis
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Diagnosis and treatment of benign paroxysmal positional vertigo in common clinical practice
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Pharmacoepidemiological study of the course of influenza and other acute respiratory viral infections in risk groups
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Myeloproliferative masks of multiple myeloma: A review of literature and clinical case reports
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Autoimmune hemolytic anemia associated with mesenteric teratoma
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Use of pharmacogenetic testing to prevent adverse drug reactions during statin therapy
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Myocardial fibrosis: Current aspects of the problem
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Algorithm for the management of patients with stable coronary artery disease and high-grade ventricular arrhythmias
Abstract
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Obstructive sleep apnea at high altitude
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The problem of obstructive sleep apnea syndrome in asthmatic patients
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Idiopatic pulmonary fibrosis: A new paradigm
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Chronic obstructive pulmonary disease concurrent with metabolic syndrome: Pathophysiological and clinical features
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Involvement of the hepatobiliary system and pancreas in obesity
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Sergey Anatolyevich Boytsov (on the occasion of the 60th anniversary of his birth)
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