Vol 60, No 10 (2024)

Using the cyclic voltammetry method, the electrochemical and electrocatalytic properties for hydrogen evolution reaction of the 1-hydro-1,10-phenanthrolinium perchlorate (I) and 1,10-dihydro-1,10-phenanthrolinium perchlorate (II) in the presence of CF3COOH were studied. The presence of hydrogen atoms at nitrogen in heterocyclic compounds has a significant effect on the electrochemical properties and the efficiency of the electrocatalytic process. The transition from 1-hydro-1,10-phenanthrolinium perchlorate (I) to 1,10-dihydro-1,10-phenanthrolinium perchlorate (II) leads to an increase in the efficiency of the process (higher TOF and TON values), despite identical mechanisms. The DFT method was used to study the mechanisms of the processes taking place and identify key intermediates.

Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers were synthesized. In order to increase their hydrophilicity and potential biological activity, pharmacophore electron-deficient groups (carboxylic, nitrile) were introduced into the molecule. Functionalized compounds revealed a new type of biological activity such as inhibition of lipid oxidation in the form of a decrease in the amount of MDA.

The interaction of N1-phenyl- and N1-(4-methoxyphenyl)phenylene-1,4-diamines with maleic anhydride produced the corresponding monoamides of maleic acid, cyclization of which in the presence of p-toluene sulfonic acid synthesized N-[4-(N1-phenylamino)- or N1-(4-methoxyphenylamino)]phenyl-1H-pyrrole-2,5-diones.

Quantum chemical modeling of the mechanism of interaction of propargyl chloride with potassium 1,2-ethanedithiolate in the hydrazine hydrate–KOH system was carried out using the combined approach CCSD(T)/6-31+G*//B3LYP/6-311++G**. The elementary stages of the reaction and possible routes for the heterocyclization of the initial intermediates have been found. Under experimental conditions at a reaction temperature of 40-42°C, 6 hours, 2-methyl-5,6-dihydro-1,4-dithiine was obtained with a yield of 25% and 4,7-dithiadecadiine-2,8 with a yield of 24%. At a temperature of –10 ÷ –15°С, cyclic products are not formed.

Based on 2-mercaptobenzoic acid hydrazide and commercially available formaldehyde and acrolein, a two-step method for the synthesis of a previously unknown 1-hydroxy-2,3-dihydropyrazolo[1,2-c]benzo-1,3,4-thiadiazepin-11(5H)-one, as a compound with a targeted antitumor effect, as well as a promising bioactive co-ligand for obtaining of gold glyco-nanoparticles for the biomedical purposes was developed

A method has been developed for the preparation of polyfunctional pyridine derivatives — 6′-amino-4′-aryl-3′,5′-dicyano-[1,2′-bipyridine]-1-ium chlorides based on simple precursors of malononitrile and aldehydes.