The Sintesis and Antioxidant Activity of New bis-1,3,4-Oxadiazoles, bis-1,3,4-Thiadiazoles, and Their Derivatives

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Abstract

Bis-1,3,4-oxadiazoles and bis-1,3,4-thiadiazoles with aryl and alkyl linkers were synthesized. In order to increase their hydrophilicity and potential biological activity, pharmacophore electron-deficient groups (carboxylic, nitrile) were introduced into the molecule. Functionalized compounds revealed a new type of biological activity such as inhibition of lipid oxidation in the form of a decrease in the amount of MDA.

About the authors

S. V. Dilanyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Author for correspondence.
Email: nana_dilanyan@mail.ru
ORCID iD: 0000-0003-1786-5548
Armenia, prosp. Azatutyan, 26, Yerevan, 0014

Zh. M. Buniatyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: nana_dilanyan@mail.ru
ORCID iD: 0000-0002-3152-3176
Armenia, prosp. Azatutyan, 26, Yerevan, 0014

H. A. Panosyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: nana_dilanyan@mail.ru
ORCID iD: 0000-0001-8311-6276
Armenia, prosp. Azatutyan, 26, Yerevan, 0014

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