Acute lymphoblastic leukemias with translocations (1;19)(q23;p13): a description of 3 new cases and a review of the literature


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Abstract

Aim. To discuss the specific features of the cytogenetics and clinical manifestations of acute lymphoblastic leukemias (ALL) with balanced and unbalanced translocations (1;19)(q23; p13).
Materials and methods. Bone marrow cells with differential staining of chromosomes into G-segments underwent cytogenetic study that was added by fluorescence in situ hybridization in 2 cases. The karyotypes of 3 patients with ALL previously untreated at 5, 18, and 23 years of age were studied.
Results. Balanced translocations (1;19)(q23; p13) were found in 2 of the examinees while unbalanced translocation was noted in 1 case. Modal chromosomal classes were 46, 47, and 55-65 if the cells had additional structural (+1q, 6q-, etc.) and numerical chromosomal abnormalities (nonrandom trisomies and tetrasomies of chromosomes of different pairs).
Conclusion. Translocation (1;19)(q23; p13) is characteristic for patients of different age groups, mainly for those with pre-B cell ALL. It is commonly concurrent with other karyotypic changes, namely, 6q deletion, 1q trisomy, and high hyperdiploidy.

About the authors

Tat'yana Leonidovna Gindina

Email: tatgindina@rambler.ru

Nikolay Nikolaevich Mamaev

Email: nikmamaev@rambler.ru

Svetlana Rafikovna Zubaydullina

Email: svetuk_s@mail.ru

Elena Viktorovna Kondakova

Email: kondakovae@mail.ru

T L Gindina

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

N N Mamayev

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University

S R Zubaidullina

Medical Genetic Counseling Center, District Cardiology Dispensary

Medical Genetic Counseling Center, District Cardiology Dispensary

E V Kondakova

Surgut District Clinical Hospital

Surgut District Clinical Hospital

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