Acute lymphoblastic leukemias with translocations (1;19)(q23;p13): a description of 3 new cases and a review of the literature
- 作者: Gindina T.L.1, Mamaev N.N.1, Zubaydullina S.R.1, Kondakova E.V.1, Gindina TL2, Mamayev NN2, Zubaidullina SR3, Kondakova EV4
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隶属关系:
- R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University
- Medical Genetic Counseling Center, District Cardiology Dispensary
- Surgut District Clinical Hospital
- 期: 卷 82, 编号 11 (2010)
- 页面: 63-67
- 栏目: Editorial
- ##submission.dateSubmitted##: 09.04.2020
- ##submission.datePublished##: 15.11.2010
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30755
- ID: 30755
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Materials and methods. Bone marrow cells with differential staining of chromosomes into G-segments underwent cytogenetic study that was added by fluorescence in situ hybridization in 2 cases. The karyotypes of 3 patients with ALL previously untreated at 5, 18, and 23 years of age were studied.
Results. Balanced translocations (1;19)(q23; p13) were found in 2 of the examinees while unbalanced translocation was noted in 1 case. Modal chromosomal classes were 46, 47, and 55-65 if the cells had additional structural (+1q, 6q-, etc.) and numerical chromosomal abnormalities (nonrandom trisomies and tetrasomies of chromosomes of different pairs).
Conclusion. Translocation (1;19)(q23; p13) is characteristic for patients of different age groups, mainly for those with pre-B cell ALL. It is commonly concurrent with other karyotypic changes, namely, 6q deletion, 1q trisomy, and high hyperdiploidy.
作者简介
Tat'yana Gindina
Email: tatgindina@rambler.ru
Nikolay Mamaev
Email: nikmamaev@rambler.ru
Svetlana Zubaydullina
Email: svetuk_s@mail.ru
Elena Kondakova
Email: kondakovae@mail.ru
T Gindina
R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical UniversityR. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University
N Mamayev
R. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical UniversityR. M. Gorbacheva Institute of Pediatric Hematology and Transplantology, Acad. I. P. Pavlov Saint Petersburg State Medical University
S Zubaidullina
Medical Genetic Counseling Center, District Cardiology DispensaryMedical Genetic Counseling Center, District Cardiology Dispensary
E Kondakova
Surgut District Clinical HospitalSurgut District Clinical Hospital
参考
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