SYNTHESIS OF 5,5-DISUBSTITUTED N-METHYL-1,3-OXAZINANES CONTAINING MONOTERPENE FRAGMENTS

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Abstract

A new method for the synthesis of 5,5-disubstituted N-methyl-1,3-oxazinanes as a mixture of diastereomers at position 5 containing monoterpene and branched alkyl substituents at position 5 has been developed. The 1,3-oxazinanes were obtained for the first time by the interaction of 2,2-substituted 3-aminopropane-1-ols with formaldehyde and sodium borohydrides in a single stage.

About the authors

I. V. Nechepurenko

Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCH SB RAS)

Author for correspondence.
Email: niv@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk

K. P. Volcho

Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCH SB RAS)

Email: niv@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk

N. F. Salakhutdinov

Vorozhtsov Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences (NIOCH SB RAS)

Email: niv@nioch.nsc.ru
Russian Federation, 630090, Novosibirsk

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Copyright (c) 2023 И.В. Нечепуренко, К.П. Волчо, Н.Ф. Салахутдинов