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Modification of N-functionalized 4-nitroso-1H-pyrazoles
- Authors: Bobrova A.V.1, Golenko E.I.1, Oberenko A.V.2, Ivanenko T.Y.3, Root E.V.1,4, Suboch G.A.1
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Affiliations:
- Reshetnev Siberian State University of Science and Technology
- Siberian Federal University
- Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center ‘Krasnoyarsk Science Center SB RAS’
- Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenetsky
- Issue: Vol 60, No 5 (2024)
- Pages: 654-659
- Section: Articles
- URL: https://ter-arkhiv.ru/0514-7492/article/view/685345
- DOI: https://doi.org/10.31857/S0514749224050091
- EDN: https://elibrary.ru/RCVSVA
- ID: 685345
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Abstract
N-substituted 3,5-dimethyl-4-nitroso-1H-pyrazoles was oxidized and reduced. The resulting 4-aminopyrazole was acylated, diazotized with further azo coupling or amino group replacement by iodine. Aminopyrazole was also condensed with 4-nitrobenzaldehyde. The first condensation of nitrosopyrazole with 2,4-dinitrotoluene was shown. As a result, new functionalised pyrazole derivatives were isolated. The structure of novel pyrazoles was confirmed by IR, 1H, 13C NMR spectroscopy, gas chromatography-mass spectrometry, and elemental analysis. The obtained compounds are promising for further research in medicine and pharmaceutical chemistry.
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About the authors
A. V. Bobrova
Reshetnev Siberian State University of Science and Technology
Author for correspondence.
Email: anastasiya-an-96@mail.ru
ORCID iD: 0000-0002-9264-4449
Russian Federation, Krasnoyarskii Rabochii prosp., 31, Krasnoyarsk, 660037
E. I. Golenko
Reshetnev Siberian State University of Science and Technology
Email: anastasiya-an-96@mail.ru
ORCID iD: 0009-0001-1413-6318
Russian Federation, Krasnoyarskii Rabochii prosp., 31, Krasnoyarsk, 660037
A. V. Oberenko
Siberian Federal University
Email: anastasiya-an-96@mail.ru
ORCID iD: 0000-0002-1156-9644
Russian Federation, Svobodny prosp., 79, Krasnoyarsk, 660041
T. Y. Ivanenko
Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center ‘Krasnoyarsk Science Center SB RAS’
Email: anastasiya-an-96@mail.ru
ORCID iD: 0000-0002-1931-3205
Russian Federation, Akademgorodok, 50/24, Krasnoyarsk, 660036
E. V. Root
Reshetnev Siberian State University of Science and Technology; Krasnoyarsk State Medical University named after prof. V.F. Voino-Yasenetsky
Email: anastasiya-an-96@mail.ru
ORCID iD: 0009-0001-7093-4701
Russian Federation, Krasnoyarskii Rabochii prosp., 31, Krasnoyarsk, 660037; ul. Partizana Zheleznyaka, 1, Krasnoyarsk, 660022
G. A. Suboch
Reshetnev Siberian State University of Science and Technology
Email: anastasiya-an-96@mail.ru
ORCID iD: 0000-0003-2027-8512
Russian Federation, Krasnoyarskii Rabochii prosp., 31, Krasnoyarsk, 660037
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