Vol 79, No 10 (2004)

Aim. To study efficacy and tolerance ofpirasidol in elderly patients with somatic diseases and depression. Material and methods. The study was made in 30 patients over 55 years of age with a mild or moderate depressive episode. The efficacy of a 6 week treatment with pirasidol was assessed by somatic examination, Hamilton depressive scale (17 points), General Clinical Impression Scale, 5-score subjective state scale. Results. Pirasidol treatment led to a 36% decrease in intake of drugs. The patients took much lower doses of non-narcotic analgetics, nitroglycerine, tranquilizers, enzymatic medicines. The highest efficacy was seen in patients with exacerbation of somatic diseases which reduced faster in addition of prasidol to somatotropic therapy. Pirasidol is well tolerated, no interaction with other drugs was found. Conclusion. The antidepressant pirasidol showed efficacy against depression in elderly patients with somatic pathology. It can be recommended as a drug of choice for treatment of depression in eldely patients with somatic diseases.

Aim. To compare efficacy and tolerance of tonocardin (doxazosin) and omnik (tamsulosin) in the treatment of benign prostatic hyperplasia (BPH) in hypertensive patients. Material and methods. Group 1 patients (n = 115, age 44-81 years) with BPH and mild or moderate arterial hypertension (AH) treated with one antihypertensive drug (ACE inhibitor - 48, calcium antagonist - 26, beta-blocker - 22, diuretic - 19) were given tonocardin in a single daily dose from 1 to 4 mgfor 12 weeks. Group 2 patients (n ~ 30, age 67-81 years) with BPH and severe AH treated with two antihypertensive drugs and more were given omnik in a single daily dose 0.4 mgfor 12 weeks. Results. In group 1, tonocardin treatment resulted in lowering of a total symptoms score by IPSS scale from 17.5 ± 3.6 to 14.7 ± 1.3 points, of quality of life from 4.3 ±0.7 to 3.9 ± 0.3, in a rise of maximal velocity of urine flow (Qmax) from 7.8 ± 1.2 to 9.4 ± 0.6 ml/s; residual urine (R) reduced from 112.4 ± 8.6 to 64.5 ± 10.2 ml). Systolic arterial pressure went down from 150.5 ± 13 to 139.8 ± 13.3 mm Hg, diastolic pressure fell from 86.9 ± 6.1 to 80.8 ± 7.1 mm Hg. In group 2, omnik resulted in IPSS scale points lowering from 17. 7 ± 3.5 to 15 ± 1.1 , QOL from 4.5 ± 0.2 to 3.8 ± 0.2, Qmax from 7.4 ± 1.1 to 9.2 ± 0.5 ml/s, Rfrom 107.5 ± 12.7 to 63.4 ±9.7 ml. Arterial pressure did not change much. Conclusion. Tonocardin and omnik are effective and safe not only in the treatment of BPH but also of BPH combination with AH.

Aim. To study knowledge of cardiovascular disease (CVD) risk factors (RF) in open population of Tyumen with reference to social gradient. Material and methods. Knowledge of CVD RF was studied in 2248 citizens of Tyumen (men and women, age 25-64 years) by means of mail questionnaire survey. The knowledge was assessed with consideration of education, occupation and marriage status. Results. The examinees with primary education and manual labour workers were found to have little knowledge of the CVD RF while those with university education, engineers and specialists were well informed. Married population, widows and widowers knew about CVD RF more than divorced. Conclusion. The results of the study can serve a basis for a large-scale prophylactic program in open population of Tyumen.