Vol 79, No 10 (2004)

Editorial
Misdiagnosis and mistreatment of pulmonary cancer
Chissov V.I., Trakhtenberg A.K., Kolbanov K.I., Pikirt A.V.
Abstract
Terapevticheskii arkhiv. 2004;79(10):1-12
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The role of psychiatry in medicine
Piven B.N.
Abstract
Terapevticheskii arkhiv. 2004;79(10):13-16
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Effects ofprognostic parameters and radiotherapy on survival of patients with pulmonary cancer
Yuozaitite E., Inchura A., Sakalauskas R., Valius L.
Abstract
Aim. To analyze factors influencing expected survival of pulmonary cancer (PC) patients given radiotherapy, i.e. age of the patient, stage of the disease, size of the tumor, involvement of the lymph nodes, a total focal dose, space distribution of the dose. Material and methods. Among PC patients 87% were males and 73.9% were 60 years of age and older. Local PC (stage Ilia and IUb) was diagnosed in 65.2%. Non-small-cell PC was in 83.8%. Effects of radiotherapy on the survival was analysed in 115 patients. Total focal doses made up 30 Gy (3.0 Gy/10fractions) to 70 Gy (2.0 Gy/35fractions). Results. Longer survival was achieved after irradiation with greater dose and modern three-dimentional planning ofconformic radiotherapy. A significant prolongation of the survival was seen in raising the total focal dose to 50 Gy. There is a correlation between the dose and conformity of the dose distribution. During the study 58.2% patients died. Conclusion. Assessment of the survival of PC patients given radiotherapy has shown that negative prognostic factors are the following: PC stage IIIA, IHB and IV, extensive local spread of the tumor, large primary tumor, involvement of the lymph nodes.
Terapevticheskii arkhiv. 2004;79(10):17-22
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Use of interleukine-2 in a patient with renal cancer and paraneoplastic vasculitis
Demidov L.V., Semenkova E.N., Kharkevich G.Y., Timofeev I.V.
Abstract
Terapevticheskii arkhiv. 2004;79(10):23-24
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Present-day antidepressants:new perspectives in general clinical practice (a review)
Mosolov S.N., Kostyukova E.G.
Abstract
Terapevticheskii arkhiv. 2004;79(10):25-31
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Pirasidol treatment of depression in elderly patients with somatic disease
Spasova S.A.
Abstract
Aim. To study efficacy and tolerance ofpirasidol in elderly patients with somatic diseases and depression. Material and methods. The study was made in 30 patients over 55 years of age with a mild or moderate depressive episode. The efficacy of a 6 week treatment with pirasidol was assessed by somatic examination, Hamilton depressive scale (17 points), General Clinical Impression Scale, 5-score subjective state scale. Results. Pirasidol treatment led to a 36% decrease in intake of drugs. The patients took much lower doses of non-narcotic analgetics, nitroglycerine, tranquilizers, enzymatic medicines. The highest efficacy was seen in patients with exacerbation of somatic diseases which reduced faster in addition of prasidol to somatotropic therapy. Pirasidol is well tolerated, no interaction with other drugs was found. Conclusion. The antidepressant pirasidol showed efficacy against depression in elderly patients with somatic pathology. It can be recommended as a drug of choice for treatment of depression in eldely patients with somatic diseases.
Terapevticheskii arkhiv. 2004;79(10):32-35
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Algorithm of lifequality evaluation for patients with psychosomatic diseases
Sidorov P.I., Solovyev A.G., Novikova I.A.
Abstract
Aim. To elaborate the algorithm for evaluation of quality of life (QL) in patients with psychosomatic diseases. Material and methods. AMPI, Spilberger-Khanin anxiety test, the procedures "general state, activity, mood" and "personality differential". Results. The algorithm of QL evaluation comprises a questionnaire consisting of 48 questions divided into 3 blocks. Quality of the somatic state was assessed by restrictions in exercise, self-care, everyday activity. A psychological component of QL was determined by the presence of depression, anxiety, emotional effects on everyday and professional activity; the social component - by relations in office, family, medical personal. The procedure was standardized, so QL should be considered as high at 97144 points, good 87-96, satisfactory 44-86, unsatisfactory results were at 26-43 points, poor - at 025 points. Conclusion. The proposed technique of QL of psychosomatic patients proved its validity and reliability. Therefore, it can be recommended for design of psychosocial and medical rehabilitative measures as well as for assessment of efficacy of these measures.
Terapevticheskii arkhiv. 2004;79(10):36-42
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Vertigo in neurological and therapeutic practice(lecture)
Golubev V.L.
Abstract
Terapevticheskii arkhiv. 2004;79(10):43-48
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Diagnosis andtreatment of hypothyroidism: current principles (a review)
Fadeev V.V., Morgunova Т.В., Zakharova S.M., Buziashvili I.I., Usacheva V.Y., Melnichenko G.A.
Abstract
Terapevticheskii arkhiv. 2004;79(10):49-53
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Metabolic syndrome of insulin resistance: basic conception and consequences (a review)
Starkova N.Т., Dvoryashina I.V.
Abstract
Terapevticheskii arkhiv. 2004;79(10):54-57
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Physiological role and significance of magnesium in therapy (a review)
Gromova О.A.
Abstract
Terapevticheskii arkhiv. 2004;79(10):58-62
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Pathogenesisand diagnosis of chronic venous insufficiency. Update.(lecture)
Karalkin A.V., Albitsky A.V., Kuznetsov A.N.
Abstract
Terapevticheskii arkhiv. 2004;79(10):63-67
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Current trends in therapy of chronic venous insufficiency (lecture)
Kirienko A.I., Albitsky A.V., Kuznetsov A.N., Agafonov V.F., Golovanova O.V.
Abstract
Terapevticheskii arkhiv. 2004;79(10):68-71
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Use of alpha-adrenoblockers intherapy of benign prostatic hyperplasia in patients with arterial hypertension
Mazo E.В., Shashin M.N.
Abstract
Aim. To compare efficacy and tolerance of tonocardin (doxazosin) and omnik (tamsulosin) in the treatment of benign prostatic hyperplasia (BPH) in hypertensive patients. Material and methods. Group 1 patients (n = 115, age 44-81 years) with BPH and mild or moderate arterial hypertension (AH) treated with one antihypertensive drug (ACE inhibitor - 48, calcium antagonist - 26, beta-blocker - 22, diuretic - 19) were given tonocardin in a single daily dose from 1 to 4 mgfor 12 weeks. Group 2 patients (n ~ 30, age 67-81 years) with BPH and severe AH treated with two antihypertensive drugs and more were given omnik in a single daily dose 0.4 mgfor 12 weeks. Results. In group 1, tonocardin treatment resulted in lowering of a total symptoms score by IPSS scale from 17.5 ± 3.6 to 14.7 ± 1.3 points, of quality of life from 4.3 ±0.7 to 3.9 ± 0.3, in a rise of maximal velocity of urine flow (Qmax) from 7.8 ± 1.2 to 9.4 ± 0.6 ml/s; residual urine (R) reduced from 112.4 ± 8.6 to 64.5 ± 10.2 ml). Systolic arterial pressure went down from 150.5 ± 13 to 139.8 ± 13.3 mm Hg, diastolic pressure fell from 86.9 ± 6.1 to 80.8 ± 7.1 mm Hg. In group 2, omnik resulted in IPSS scale points lowering from 17. 7 ± 3.5 to 15 ± 1.1 , QOL from 4.5 ± 0.2 to 3.8 ± 0.2, Qmax from 7.4 ± 1.1 to 9.2 ± 0.5 ml/s, Rfrom 107.5 ± 12.7 to 63.4 ±9.7 ml. Arterial pressure did not change much. Conclusion. Tonocardin and omnik are effective and safe not only in the treatment of BPH but also of BPH combination with AH.
Terapevticheskii arkhiv. 2004;79(10):72-74
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Erectile dysfunction in patients withischemic heart disease (review)
Gamidov S.I., Mazo E.В., Ovchinnikov R.I., Kurochkin E.E., Iremashvili V.V.
Abstract
Terapevticheskii arkhiv. 2004;79(10):75-79
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Basic therapy of rheumatoid arthritis with leflunomide (review)
Olyunin Y.A.
Abstract
Terapevticheskii arkhiv. 2004;79(10):80-84
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ACE inhibitors in the treatment of ischemicheart disease and prevention of its complications (review)
Schekotov V.V.
Abstract
Terapevticheskii arkhiv. 2004;79(10):85-88
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Periportal cardiomyopathy (a case report)
Pavlov V.V., Lineva О.I., Khutorskaya N.N., Agafonova О.V., Vanyagina Z.P., Zubrilkina L.G.
Abstract
Terapevticheskii arkhiv. 2004;79(10):89-90
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Significance of antibacterial therapy of Chlamydophila pneumoniae infection in patients with bronchial asthma
Khamitov R.F., Palmova L.Y., Novozhenov V.G.
Abstract
Aim. To study effects of eradication of Chlamydophila pneumoniae CP) infection in bronchial asthma (BA) on BA course and changes in quality of life (QOL) in BA patients. Material and methods. 194 BA patients in clinical remission participated in the trial. Microbiological diagnosis of asymptomatic CP infection was made serologically (ELISA, indirect enzyme immunoassay) using polymerase chain reaction. Clinical and biochemical tests, assessment of pulmonary ventilation function, QOL by AQLQ during 6-week antimicrobial therapy were made in 56patients. Results. Patients with stable BA had high frequency of serological signs of clinically asymptomatic CP infection (52%) deteriorating BA symptoms and QOL. Antibacterial therapy of latent CP infection with azitromycin significantly improved BA course and QOL ofBA patients. Conclusion. When laboratory tests detect CP infection in patients with long-term course of BA, especially in smoking males with moderate and severe BA it is clinically valid to prescribe addition of azitromycin to basic antiinflammatory treatment of BA.
Terapevticheskii arkhiv. 2004;79(10):91-93
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Knowledge ofcardiovascular disease risk factors in open population of Tyumen and social gradient
Akimova E.V., Gafarov V.V., Kuznetsov V.A.
Abstract
Aim. To study knowledge of cardiovascular disease (CVD) risk factors (RF) in open population of Tyumen with reference to social gradient. Material and methods. Knowledge of CVD RF was studied in 2248 citizens of Tyumen (men and women, age 25-64 years) by means of mail questionnaire survey. The knowledge was assessed with consideration of education, occupation and marriage status. Results. The examinees with primary education and manual labour workers were found to have little knowledge of the CVD RF while those with university education, engineers and specialists were well informed. Married population, widows and widowers knew about CVD RF more than divorced. Conclusion. The results of the study can serve a basis for a large-scale prophylactic program in open population of Tyumen.
Terapevticheskii arkhiv. 2004;79(10):94-96
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