Effects ofprognostic parameters and radiotherapy on survival of patients with pulmonary cancer


Cite item

Full Text

Abstract

Aim. To analyze factors influencing expected survival of pulmonary cancer (PC) patients given radiotherapy, i.e. age of the patient, stage of the disease, size of the tumor, involvement of the lymph nodes,
a total focal dose, space distribution of the dose.
Material and methods. Among PC patients 87% were males and 73.9% were 60 years of age and
older. Local PC (stage Ilia and IUb) was diagnosed in 65.2%. Non-small-cell PC was in 83.8%. Effects of radiotherapy on the survival was analysed in 115 patients. Total focal doses made up 30 Gy
(3.0 Gy/10fractions) to 70 Gy (2.0 Gy/35fractions).
Results. Longer survival was achieved after irradiation with greater dose and modern three-dimentional planning ofconformic radiotherapy. A significant prolongation of the survival was seen in raising
the total focal dose to 50 Gy. There is a correlation between the dose and conformity of the dose distribution. During the study 58.2% patients died.
Conclusion. Assessment of the survival of PC patients given radiotherapy has shown that negative
prognostic factors are the following: PC stage IIIA, IHB and IV, extensive local spread of the tumor,
large primary tumor, involvement of the lymph nodes.

References

  1. Pagrindiniai onkologines pagalbos rezultatai Lietuvoje. 2001 metai (ataskaitiniii formii f. 12 ir f. 24 duomenys). (The main results of oncological care in Lithuania. 2001 year.) Vilnius; 2002.
  2. Sandler H. M., Curron W. J., Turisi A. T. The influenze of tumor size and pre-treatment staging on outcome following radiation therapy alone for Stage I non-small cell lung cancer. Int.J. Radiat. Oncol. Biol. Phys. 1990; 19: 9-13.
  3. Jeremic В., Shibamoto Y. Pre-treatment prognostic factors in patients with stage III non-small cell lung cancer treated with' hyperfractionated radiation therapy with or without concurrent chemotherapy. Lung Cancer 1995; 13(1): 21-30.
  4. Talton B. M., Constable W. C, Kersch С R. Curative radiotherapy in non-small carcinoma of the lung. Int. J. Radiat. Oncol. Biol. Phys. 1990; 19: 15-21.
  5. Graham P. H., Stat G M., Langlands A. O. Radical radiotherapy for early nonsmall cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 1995; 31:261-266.
  6. Fletcher G. Clinical dose-response curves of human malignant epithelial tumours. Br. J. Radiol. 1973; 46: 1-12.
  7. PORT Meta-analysis Trialists Group. Postoperative radiotherapy in non-small-cell lung cancer: a systemic review and metaanalysis of individual patient data from nine randomised controlled trials. Lancet 1998; 352: 257-263.
  8. Sause W., Scott C, Byhardt R. et al. Combined chemotherapy and radiation therapy treatment in unresected non-small cell lung cancer Radiation Therapy Oncology Group (RTOG) experience. Lung Cancer 2000; 29(suppl. 2).
  9. Willner J., Caragiani E., Tschamler A. et al. The influence of total dose and tumor volume on local control and survival an поп small cell lung cancer. Int, J. Radiat. Oncol. Biol. Phys. 2000; 48(3, suppl.): 2127.
  10. Emami В., Lyman J., Brown A. et al. Tolerance of normal tissue to therapeuric irradiation. Int. J. Radiat. Oncol. Biol. Phys. 1991; 21: 109-112.
  11. Dosoretz D. £., Katin M. J., Blitzer P. H. et al. Medically inoperable lung carcinoma: The role of radiation therapy. Semin. Radiat. Oncol. 1996; 6(2): 98-104.
  12. Checkliste onkologie / Senn H. J., Drings P., Glaus A. et al. Stuttgart; New York; 2001. 245-257.
  13. Pazdur R., Coia L. R., Hoskins W. J., Wagman L. D. Cancer management. A multidisciplinary approach. (Medical, surgical and radiation oncology). 6-th ed.; 2000.
  14. Scott W. J., Howington J., Movsas B. Treatment of stage II nonsmall cell lung cancer. Chest 2003; 123(1, suppl.): 188- 201.
  15. Bahman E. Three-dimensional conformal radiation therapy in bronchogenic carcinoma. Semin. Radiat. Oncol. 1996; 6(2): 92-97.
  16. Perez С A., Bauer M., Edelstain S. et al. Impact of tumor con- trol on survival in carcinoma of the lung treated with irradiation. Int. J. Radiat. Oncol. Biol. Phys. 1986; 12: 539-547.
  17. Emami В., Purdy J., Harms W. et al. Three dimensional treatment planning for lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 1991; 21: 217-227.
  18. Saunders M., Dische S., Barrett A. et al. Continuous hyperfrac tionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: a randomised multicentre trial. CHART Steering Committee. Lancet 1997; 350(9072): 161-165.
  19. McKenne R. J., Movsas В., Shin D. M. et al. Nonsmallcell lung cancer, mesothelioma and thymoma. In: Pazdur R., Coia L. R., Hoskins W. J., ed. Cancer management: A multidisci plinary approach. 6-th ed. New York: PRR; 2002. 111-138.
  20. Senan S., Burgers S., Samson M. J. et al. Can elective nodal irradiation be omitted in stage III nonsmallcell lung cancer? Analysis of recurrences in a phase II study of induction chemotherapy and involved-field radiotherapy. Int. J. Radiat. Oncol. Biol. Phys. 2002; 54(4): 999-1006.
  21. Jeremic В., Classen J., Bamberg M. Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer. Int. J. Radiat. Oncol. Biol. Phys. 2002; 54(1): 119-130.

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2004 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

 © 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies