Therapy of acute massive blood loss in a hemophiliac male: case report


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A case is reported of management of massive intraoperative blood loss in a male patient with severe hemophilia. Extirpation of hip pseudotumor with one-stage osteosynthesis with an intramedullary joint-pin in a 43 year old male patient was accompanied with 7.5 l blood loss. The infusion-transfusion therapy (ITT) contained transfusion media about 1/3 of the total volume, fresh-frozen plasma and erythrocyte-containing media were used 1:1. Infusion solutions consisted of balanced polyelectrolytic solutions, hydroxyethylated starches 130/0.4, hyperchaes. Intraoperative normovolemic hemodilution and reinfusion of wound blood were made (CellSaver). ITT target markers were standard hemodynamics control tests. Hemostasis monitoring was conducted with thromboelastography. Complex ITT based on modern principles of clinical transfusiology provided a complete and safe compensation of massive intraoperative blood loss in a patient with severe hemophilia.

作者简介

Andrey Bulanov

Email: buldoc68@mail.ru

Elena Shulutko

Evgeniy Karpov

Email: karpov.evg@mail.ru

Tat'yana Polyanskaya

Email: polyantat@rambler.ru

Georgiy Mishin

Sergey Morozov

Email: sergeymorozov.hrc@gmail.com

Nikolay Kalinin

Aleksandr Tochenov

Konstantin Yatskov

Vladimir Zorenko

Magomed Sampiev

A Bulanov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

E Shulutko

Hematological Research Center, Moscow

Hematological Research Center, Moscow

E Karpov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

T Polyanskaya

Hematological Research Center, Moscow

Hematological Research Center, Moscow

G Mishin

Hematological Research Center, Moscow

Hematological Research Center, Moscow

S Morozov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

N Kalinin

Hematological Research Center, Moscow

Hematological Research Center, Moscow

A Tochenov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

K Yatskov

Hematological Research Center, Moscow

Hematological Research Center, Moscow

V Zorenko

Hematological Research Center, Moscow

Hematological Research Center, Moscow

M Sampiev

Hematological Research Center, Moscow

Hematological Research Center, Moscow

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