Email this article Effect of the anti-inflammatory peptide preparation ingramon on the blood levels of acute-phase proteins and chemokines in patients after coronary stenting
- Authors: Potekhina A.V.1, Provatorov S.I.1, Aref'eva T.I.1, Kukhtina N.B.1, Masenko V.P.1, Kaznacheeva E.I.1, Ruleva N.Y.1, Noeva E.A.1, Osyaeva M.K.1, Sidorova M.V.1, Bespalova Z.D.1, Krasnikova T.L.1, Potekhina AV2, Provatorov SI2, Arefyeva TI2, Kukhtina NB2, Masenko VP2, Kaznacheyeva EI2, Ruleva NY.2, Noyeva EA2, Osyaeva MK2, Sidorova MV2, Bestalova Z.D2, Krasnikova TL2
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Affiliations:
- Russian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
- Issue: Vol 82, No 11 (2010)
- Pages: 58-63
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30752
- ID: 30752
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Abstract
Subjects and methods. The investigation enrolled 64 patients with stable angina who had undergone coronary bypass surgery, of them 34 patients received ingramon in addition to standard therapy. The blood levels of high-sensitive C-reactive protein (hs-CRP), fibrinogen, the chemokines MCP-1, IL-8, IP-10, and MID were measured before and 1, 2, and 7 days and 1, 3, and 6 months after surgery. Twenty patients who had gone coronarography (CG) only were examined as a control group.
Results. In the postCS patients receiving only standard therapy, the levels of hs-CRP and fibrinogen were much higher on days 1, 2, and 7 after surgery than in the CG patients. On day 1 following CS, the increment in hs-CRP correlated with the length of implanted stents. During ingramon therapy, the content of hs-CRP and fibrinogen was considerably lower on days 1, 2, and 7 after CS than in the control group; this trend persisted a month after surgery; there was also a reduction in MCP-1 levels within the first 24 hours after initiation of therapy. The levels of the chemokines IP-10, MIG, and IL-8 were significantly unchanged.
Conclusion. When added to standard therapy, ingramon exerts a positive effect against risk factors for coronary heart disease (CHD) and its events. Further investigations are required to define the impact of ingramon therapy on prognosis in patients with CHD.
Keywords
About the authors
Aleksandra Viktorovna Potekhina
Email: potehina@gmail.com
Sergey Il'ich Provatorov
Tat'yana Igorevna Aref'eva
Nadezhda Borisovna Kukhtina
Valeriy Pavlovich Masenko
Elena Ivanovna Kaznacheeva
Natal'ya Yur'evna Ruleva
Elena Aleksandrovna Noeva
Mariya Konstantinovna Osyaeva
Mariya Vladimirovna Sidorova
Zhanna Dmitrievna Bespalova
Tat'yana Leonidovna Krasnikova
A V Potekhina
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
S I Provatorov
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
T I Arefyeva
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
N B Kukhtina
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
V P Masenko
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
E I Kaznacheyeva
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
N Yu Ruleva
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
E A Noyeva
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
M K Osyaeva
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
M V Sidorova
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
Zh D Bestalova
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
T L Krasnikova
Russian Cardiology Research-and-Production Complex, Russian Agency for Medical TechnologiesRussian Cardiology Research-and-Production Complex, Russian Agency for Medical Technologies
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