The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital

Kristina Rubenovna Dudina; Дудина Кристина Рубеновна; Ol'ga Olegovna Znoyko; Знойко Ольга Олеговна; Yuliya Georgievna Trubitsyna; Трубицына Юлия Георгиевна; Svetlana Anatol'evna Shut'ko; Шутько Светлана Анатольевна; Vladimir Nikolaevich Kuz'min; Кузьмин Владимир Николаевич; Avet Grigor'evich Serobyan; Серобян Авет Григорьевич; Naira Rubenovna Revazyan; Ревазян Наира Рубеновна; Natal'ya Petrovna Petrova; Петрова Наталья Петровна; Natal'ya Petrovna Blokhina; Блохина Наталья Петровна; Nikolay Dmitrievich Yushchuk; Ющук Николай Дмитриевич; K R Dudina; Dudina K R; O O Znoiko; Znoiko O O; Yu G Trubitsyna; Trubitsyna Yu G; S A Shutko; Shutko S A; V N Kuzmin; Kuzmin V N; A G Serobyan; Serobyan A G; N R Revazyan; Revazyan N R; T V Petrova; Petrova T V; N P Blokhina; Blokhina N P; N D Yushchuk; Yushchuk N D

The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital

作者: Dudina K.R.¹, Znoyko O.O.¹, Trubitsyna Y.G.¹, Shut'ko S.A.¹, Kuz'min V.N.¹, Serobyan A.G.¹, Revazyan N.R.¹, Petrova N.P.¹, Blokhina N.P.¹, Yushchuk N.D.¹, Dudina KR², Znoiko OO², Trubitsyna Y.G², Shutko SA², Kuzmin VN², Serobyan AG³, Revazyan NR³, Petrova TV⁴, Blokhina NP³, Yushchuk ND²
隶属关系:
2. Moscow State University of Medicine and Dentistry
3. Infectious Diseases Clinical Hospital One, Moscow Healthcare Department
4. ZAO "NPF DNA-Technology"
期: 卷 82, 编号 11 (2010)
页面: 45-48
栏目: Editorial
##submission.dateSubmitted##: 09.04.2020
##submission.datePublished##: 15.11.2010
URL: https://ter-arkhiv.ru/0040-3660/article/view/30736
ID: 30736

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Aim: to define a role of hepatotropic (HAV, HBV, HCV, and HDV) and opportunistic hepatotropic (HGV, CMV, EBV, HHV types 1, 2, and 6) viruses in the etiological pattern of diseases accompanied by enhanced blood AlAT and AsAT activities in pregnant women.
Subjects and methods. Two hundred and eleven pregnant women, including 123 patients with chronic viral hepatitis, 74 with enhanced blood AlAT activity and no markers of viral hepatitis (EAlAT-NMVH), and 14 with acute viral hepatitis were examined.
Results. Most pregnant women with chronic HBV and HCV infections were found to have HBV DNA and HCV RNA in the blood in the presence of normal and enhanced activities of transaminases. In the EAlAT-NMVH group, there was none of the opportunistic hepatotropic viruses in more than 7% of cases. No genetic material of HAV, HBV, HCV, HDV, HGV, CMV, EBV, HHV types 1, 2, and 6 was found in the blood of all 10 patients with hepatitis of unspecified etiology.
Conclusion. In the absence of serologic data supporting the presence of infectious pathology, blood testing using the polymerase chain reaction is of low informative value in detecting opportunistic hepatotropic viruses in pregnant women with hepatitis of unspecified etiology. However, by keeping in mind that the spectrum of opportunistic hepatotropic viruses is not confined to those included in this study, it is expedient to examine additionally pregnant women with enhanced blood AlAT and AsAT activity in order to identify TTV, B19V, HHV-8, SEN and NV-F in the blood.

关键词

pregnancy, hepatotropic viruses, chronic viral hepatitis, AlAT, AsAT, hepatitis of unspecified etiology

参考

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The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital

全文:

详细

关键词

作者简介

Kristina Dudina

Ol'ga Znoyko

Yuliya Trubitsyna

Svetlana Shut'ko

Vladimir Kuz'min

Avet Serobyan

Naira Revazyan

Natal'ya Petrova

Natal'ya Blokhina

Nikolay Yushchuk

K Dudina

O Znoiko

Yu Trubitsyna

S Shutko

V Kuzmin

A Serobyan

N Revazyan

T Petrova

N Blokhina

N Yushchuk

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