Email this article The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital
- Authors: Dudina K.R.1, Znoyko O.O.1, Trubitsyna Y.G.1, Shut'ko S.A.1, Kuz'min V.N.1, Serobyan A.G.1, Revazyan N.R.1, Petrova N.P.1, Blokhina N.P.1, Yushchuk N.D.1, Dudina KR2, Znoiko OO2, Trubitsyna Y.G2, Shutko SA2, Kuzmin VN2, Serobyan AG3, Revazyan NR3, Petrova TV4, Blokhina NP3, Yushchuk ND2
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Affiliations:
- Moscow State University of Medicine and Dentistry
- Infectious Diseases Clinical Hospital One, Moscow Healthcare Department
- ZAO "NPF DNA-Technology"
- Issue: Vol 82, No 11 (2010)
- Pages: 45-48
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30736
- ID: 30736
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Abstract
Subjects and methods. Two hundred and eleven pregnant women, including 123 patients with chronic viral hepatitis, 74 with enhanced blood AlAT activity and no markers of viral hepatitis (EAlAT-NMVH), and 14 with acute viral hepatitis were examined.
Results. Most pregnant women with chronic HBV and HCV infections were found to have HBV DNA and HCV RNA in the blood in the presence of normal and enhanced activities of transaminases. In the EAlAT-NMVH group, there was none of the opportunistic hepatotropic viruses in more than 7% of cases. No genetic material of HAV, HBV, HCV, HDV, HGV, CMV, EBV, HHV types 1, 2, and 6 was found in the blood of all 10 patients with hepatitis of unspecified etiology.
Conclusion. In the absence of serologic data supporting the presence of infectious pathology, blood testing using the polymerase chain reaction is of low informative value in detecting opportunistic hepatotropic viruses in pregnant women with hepatitis of unspecified etiology. However, by keeping in mind that the spectrum of opportunistic hepatotropic viruses is not confined to those included in this study, it is expedient to examine additionally pregnant women with enhanced blood AlAT and AsAT activity in order to identify TTV, B19V, HHV-8, SEN and NV-F in the blood.
About the authors
Kristina Rubenovna Dudina
Email: dudinakr@mail.ru
Ol'ga Olegovna Znoyko
Email: fogelsang@mtu-net.ru
Yuliya Georgievna Trubitsyna
Email: trubit.yul@mail.ru
Svetlana Anatol'evna Shut'ko
Email: svetadindyaeva@yandex.ru
Vladimir Nikolaevich Kuz'min
Email: vnkuzmin@rambler.ru
Avet Grigor'evich Serobyan
Email: ikb_1@mail.ru
Naira Rubenovna Revazyan
Email: ikb_1@mail.ru
Natal'ya Petrovna Petrova
Email: tpetrova@dnatechnology.ru
Natal'ya Petrovna Blokhina
Email: propeg@mail.ru
Nikolay Dmitrievich Yushchuk
Email: shishkina.75@mail.ru
K R Dudina
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
O O Znoiko
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
Yu G Trubitsyna
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
S A Shutko
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
V N Kuzmin
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
A G Serobyan
Infectious Diseases Clinical Hospital One, Moscow Healthcare DepartmentInfectious Diseases Clinical Hospital One, Moscow Healthcare Department
N R Revazyan
Infectious Diseases Clinical Hospital One, Moscow Healthcare DepartmentInfectious Diseases Clinical Hospital One, Moscow Healthcare Department
T V Petrova
ZAO "NPF DNA-Technology"ZAO "NPF DNA-Technology"
N P Blokhina
Infectious Diseases Clinical Hospital One, Moscow Healthcare DepartmentInfectious Diseases Clinical Hospital One, Moscow Healthcare Department
N D Yushchuk
Moscow State University of Medicine and DentistryMoscow State University of Medicine and Dentistry
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