The etiological pattern of diseases in pregnant women with enhanced blood AlAT and AsAT activities, admitted to the obstetric unit of an infectious diseases hospital


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Abstract

Aim: to define a role of hepatotropic (HAV, HBV, HCV, and HDV) and opportunistic hepatotropic (HGV, CMV, EBV, HHV types 1, 2, and 6) viruses in the etiological pattern of diseases accompanied by enhanced blood AlAT and AsAT activities in pregnant women.
Subjects and methods. Two hundred and eleven pregnant women, including 123 patients with chronic viral hepatitis, 74 with enhanced blood AlAT activity and no markers of viral hepatitis (EAlAT-NMVH), and 14 with acute viral hepatitis were examined.
Results. Most pregnant women with chronic HBV and HCV infections were found to have HBV DNA and HCV RNA in the blood in the presence of normal and enhanced activities of transaminases. In the EAlAT-NMVH group, there was none of the opportunistic hepatotropic viruses in more than 7% of cases. No genetic material of HAV, HBV, HCV, HDV, HGV, CMV, EBV, HHV types 1, 2, and 6 was found in the blood of all 10 patients with hepatitis of unspecified etiology.
Conclusion. In the absence of serologic data supporting the presence of infectious pathology, blood testing using the polymerase chain reaction is of low informative value in detecting opportunistic hepatotropic viruses in pregnant women with hepatitis of unspecified etiology. However, by keeping in mind that the spectrum of opportunistic hepatotropic viruses is not confined to those included in this study, it is expedient to examine additionally pregnant women with enhanced blood AlAT and AsAT activity in order to identify TTV, B19V, HHV-8, SEN and NV-F in the blood.

About the authors

Kristina Rubenovna Dudina

Email: dudinakr@mail.ru

Ol'ga Olegovna Znoyko

Email: fogelsang@mtu-net.ru

Yuliya Georgievna Trubitsyna

Email: trubit.yul@mail.ru

Svetlana Anatol'evna Shut'ko

Email: svetadindyaeva@yandex.ru

Vladimir Nikolaevich Kuz'min

Email: vnkuzmin@rambler.ru

Avet Grigor'evich Serobyan

Email: ikb_1@mail.ru

Naira Rubenovna Revazyan

Email: ikb_1@mail.ru

Natal'ya Petrovna Petrova

Email: tpetrova@dnatechnology.ru

Natal'ya Petrovna Blokhina

Email: propeg@mail.ru

Nikolay Dmitrievich Yushchuk

Email: shishkina.75@mail.ru

K R Dudina

Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry

O O Znoiko

Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry

Yu G Trubitsyna

Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry

S A Shutko

Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry

V N Kuzmin

Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry

A G Serobyan

Infectious Diseases Clinical Hospital One, Moscow Healthcare Department

Infectious Diseases Clinical Hospital One, Moscow Healthcare Department

N R Revazyan

Infectious Diseases Clinical Hospital One, Moscow Healthcare Department

Infectious Diseases Clinical Hospital One, Moscow Healthcare Department

T V Petrova

ZAO "NPF DNA-Technology"

ZAO "NPF DNA-Technology"

N P Blokhina

Infectious Diseases Clinical Hospital One, Moscow Healthcare Department

Infectious Diseases Clinical Hospital One, Moscow Healthcare Department

N D Yushchuk

Moscow State University of Medicine and Dentistry

Moscow State University of Medicine and Dentistry

References

  1. Ch'ng C. L., Morgan M., Hainsworth I., Kingham J. G. C. Prospective study of liver dysfunction in pregnancy in Southwest Wales. Gut 2002; 51: 876-880.
  2. Steingrub J. S. Pregnancy-associated severe liver dysfunction. Crit. Care Clin. 2004; 20(4): 763-776.
  3. Rahman T. M., Wendon J. Severe hepatic dysfunction in pregnancy. Quart. J. Med. 2002; 95: 343-357.
  4. Wong H. Y., Tan J. Y., Lim C. C. Abnormal liver function tests in the symptomatic pregnant patient: the local experience in Singapore. Ann. Acad. Med. Singapore 2004; 33(2): 204-208.
  5. Hermida R. C., Ayala D. E., Mojon A. et al. Blood pressure patterns in normal pregnancy, gestational hypertension, and preeclampsia. Hypertension 2000; 36: 149-158.
  6. Kaaja R. J., Moore M. P., Yandle T. G. et al. Blood pressure and vasoactive hormones in mild preeclampsia and normal pregnancy. Hypertens. Pregnancy 1999; 18: 173-187.
  7. Abbassi-Ghanavati M., Greer L. G., Cunningham F. G. Pregnancy and laboratory studies: a reference table for clinicians. Obstetr. and Gynecol. 2009;114(6): 1326-1331.
  8. Chauveau E., Martin J., Saliba F. et al. Fatal fulminating hepatitis due to Herpes simplex virus type 2 in a young immunocompetent female. Mйd. Trop. 1999; 59(1): 58-60.
  9. Малкова Е. М., Гришаева О. Н. Диагностика внутриутробных инфекций у новорожденных детей методом полимеразной цепной реакции: Метод. рекомендации для врачей. Томск: Кольцово; 2000.
  10. Ющук Н. Д., Цыганова Е. В., Знойко О. О. и др. Острый гепатит неуточненной этиологии: этиологическая структура и клинико-лабораторные особенности. Экспер. и клин. гастроэнтерол. 2009; 8: 12-18.

Copyright (c) 2010 Dudina K.R., Znoyko O.O., Trubitsyna Y.G., Shut'ko S.A., Kuz'min V.N., Serobyan A.G., Revazyan N.R., Petrova N.P., Blokhina N.P., Yushchuk N.D., Dudina K.R., Znoiko O.O., Trubitsyna Y.G., Shutko S.A., Kuzmin V.N., Serobyan A.G., Revazyan N.R., Petrova T.V., Blokhina N.P., Yushchuk N.D.

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