The role of leptin, adiponectin and insulin-resistance markers in development of early stages of chronic kidney disease and atherosclerosis of carotid arteries in obese patients
- Authors: Saginova E.A.1, Gallyamov M.G.1, Severova M.M.1, Surkova O.A.1, Fomin V.V.1, Ermakov N.V.1, Rodina A.V.1, Mukhin N.A.1, Saginova EA2, Gallyamov MG3, Severova MM2, Surkova OA3, Fomin VV2, Ermakov NV4, Rodina AV2, Mukhin NA2
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Affiliations:
- I.M. Sechenov First State Moscow Medical University
- M.V. Lomonosov State Moscow University
- Moscow Research Institute of Medical Ecology
- Issue: Vol 83, No 6 (2011)
- Pages: 47-53
- Section: Editorial
- Submitted: 10.04.2020
- Published: 15.06.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30869
- ID: 30869
Cite item
Full Text
Abstract
Material and methods. The examination of 86 obese patients (64 males and 22 females, mean age 44±11 years) included standard clinical tests, test for albuminuria, calculation of glomerular filtration rate (GFR) by MDRD formula, ultrasound investigation of the carotid arteries to detect atherosclerotic lesion of the carotid arteries, assessment of insulin resistance -IR (plasma concentration of insulin before meal and blood C-peptide, HOMA-index), test for plasma adipokinins (leptin, adiponectin).
Results. Significant direct correlations were found between blood plasma leptin concentration, body mass index (BMI), plasma concentration of insulin and C-peptide, HOMA index, adiponectinemia and albuminuria. CKD patients have significantly higher than patients free of CKD levels of IR markers, waist circumference, BMI, leptinemia (38.2±28.8 and 21.6±19.8 ng/ml, respectively; p < 0.01). Obstructive sleep apnea syndrome was associated with higher IR and albuminuria, significantly lower estimated GFR (81±2 and 95±2 ml/min/1.73 m2, respectively; p < 0.05). Ultrasound evidence for atherosclerotic lesions of the carotid arteries was associated with a significant increase in blood plasma concentration of C-peptide, reduction of adiponectinemia (14.9±10.8 and 32.5±22.5 mcg/ml; p < 0.01), a rise in proportion fasting insulinemia/adiponectinemia (1.6±1.2 and 0.6±0.8, respectively; p < 0.05) and reduction of estimated GFR (86±19 and 102±25 ml/min/1.73 m2, respectively; p = 0.001).
Conclusion. In obesity, CKD at early stages develops in parallel with atherosclerotic lesion of the carotid arteries, which correlates with progression of leptinemia, IR and attenuation of organ-protecting properties of adiponectin.
About the authors
Evgeniya Andreevna Saginova
Email: med02@yandex.ru
Marat Gaptelkhakovich Gallyamov
Email: mgtabib@gmail.com
Mariya Mikhaylovna Severova
Email: mseverova@mail.ru
Ol'ga Aleksandrovna Surkova
Email: olya-d@mail.ru
Viktor Viktorovich Fomin
Email: fomin-vic@mail.ru
Nikolay Valentinovich Ermakov
Email: nivalerm@mail.ru
Alla Valer'evna Rodina
Email: allrodina@yandex.ru
Nikolay Alekseevich Mukhin
Email: moukhin-nephro@yandex.ru
E A Saginova
I.M. Sechenov First State Moscow Medical UniversityI.M. Sechenov First State Moscow Medical University
M G Gallyamov
M.V. Lomonosov State Moscow UniversityM.V. Lomonosov State Moscow University
M M Severova
I.M. Sechenov First State Moscow Medical UniversityI.M. Sechenov First State Moscow Medical University
O A Surkova
M.V. Lomonosov State Moscow UniversityM.V. Lomonosov State Moscow University
V V Fomin
I.M. Sechenov First State Moscow Medical UniversityI.M. Sechenov First State Moscow Medical University
N V Ermakov
Moscow Research Institute of Medical EcologyMoscow Research Institute of Medical Ecology
A V Rodina
I.M. Sechenov First State Moscow Medical UniversityI.M. Sechenov First State Moscow Medical University
N A Mukhin
I.M. Sechenov First State Moscow Medical UniversityI.M. Sechenov First State Moscow Medical University
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