The role of lipid disbolism in kidney disease in metabolic syndrome associated with obesity


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Abstract

Aim. To study the role of lipid metabolism impairment in renal disease in patients with metabolic syndrome associated with obesity.
Material and methods. Lipid metabolism was studied in 77 patients with metabolic syndrome (MS) aged from 17 to 63 years (mean age 48±9 years). Lipid abnormalities were analysed in groups of patients with different degree of obesity: group 1 - body mass index (BMI) 25-29.9 kg/m2 (n = 13), group 2 - BMI 30-39.9 kg/m2 (n = 49), group 3 - BMI > 40 kg/m2 (n = 15), and in groups of patients with different insulin resistance (IR) : group 1 - HOMA-IR < 2; n = 12; group 2 - HOMA-IR 2 - 4; n = 27; group 3 HOMA-IR > 4; n = 32). Correlation between plasma lipid composition abnormalities and markers of renal disease were studied with correlation analysis.
Results. Lipid disbolism in MS patients was characterized with elevated level of triglycerides, total cholesterol (TC), VLDLP cholesterol, low level of HDLP cholesterol. A significant relationship was detected between defective blood lipid composition and renal dysfunction: rise of microalbuminuria, proteinuria, creatinin, inhibition of glomerular filtration rate.
Conclusion. The changes found characterize lipid metabolism disorder as an independent factor of kidney disease in patients with MS.

About the authors

Aleksandra Aleksandrovna Kryachkova

Email: kryaka@mail.ru

S A Savel'eva

Irina Mikhaylovna Kutyrina

A A Kryachkova

I.M. Sechenov First Moscow Medical University

I.M. Sechenov First Moscow Medical University

S A Savelyeva

I.M. Sechenov First Moscow Medical University

I.M. Sechenov First Moscow Medical University

I M Kutyrina

I.M. Sechenov First Moscow Medical University

I.M. Sechenov First Moscow Medical University

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