Email this article Differential diagnosis of thymic hyperplasia and mediastinal tumor in patients with Hodgkin's lymphoma after chemotherapy
- Authors: Moiseeva T.N.1, Al'-Radi L.S.1, Shitareva I.V.1, Shevelev A.A.1, Kostina I.E.1, Kravchenko SK1, Kremenetskaya AM1, Tsyba NN1, Moiseeva TN2, Al-Radi LS2, Shitareva IV2, Shevelev AA2, Kostina IE2, Kravchenko SK2, Kremenetskaya AM2, Tsyba NN2
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Affiliations:
- Hematological Research Center, Moscow
- Issue: Vol 83, No 7 (2011)
- Pages: 47-50
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30882
- ID: 30882
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Abstract
Material and methods. The examination of 182 HD patients aged 16-71 years (median 28 years) included chest x-ray computed tomography (XCT) at baseline, during treatment, each 3 months, ultrasound investigation of the chest and abdominal cavity. All the patients received 6-8 courses of the treatment according to the program BEACOPP-14 followed by radiotherapy on the residual tumor in 137 patients, or not followed in 45 patients.
Results. Soft tissue tumor in the anterior mediastinum was detected in 14 (31%) from 45 unirradiated patients (age 19-31 years, median 24 years) 1 to 10 months (median 3.5 months) after chemotherapy. The analysis of the data of ultrasound investigation and tomography identified a mediastinal lesion as thymic hyperplasia. The patients are now in remission with follow-up median 21 months (13-36 months). No recurrence was registered.
Conclusion. Young HD patients with unirradiated mediastinum develop thymic hyperplasia in 31% cases within one year after chemotherapy. In view of this, detection of the lesion in the anterior mediastinum after CT demands complex examination for differential diagnosis of thymic hyperplasia with tumor recurrence to avoid unwanted intensification of the treatment.
About the authors
Tat'yana Nikolaevna Moiseeva
Email: taniamoiseeva@mail.ru
Lyubov' Sattarovna Al'-Radi
Email: alradi@blood.ru
Irina Vadimovna Shitareva
Aleksandr Abramovich Shevelev
Email: asw_99@mail.ru
Irina Eduardovna Kostina
Email: ikost@list.ru
S K Kravchenko
Email: krav@blood.ru
A M Kremenetskaya
N N Tsyba
Email: tsyba@blood.ru
T N Moiseeva
Hematological Research Center, MoscowHematological Research Center, Moscow
L S Al-Radi
Hematological Research Center, MoscowHematological Research Center, Moscow
I V Shitareva
Hematological Research Center, MoscowHematological Research Center, Moscow
A A Shevelev
Hematological Research Center, MoscowHematological Research Center, Moscow
I E Kostina
Hematological Research Center, MoscowHematological Research Center, Moscow
S K Kravchenko
Hematological Research Center, MoscowHematological Research Center, Moscow
A M Kremenetskaya
Hematological Research Center, MoscowHematological Research Center, Moscow
N N Tsyba
Hematological Research Center, MoscowHematological Research Center, Moscow
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