Differential diagnosis of thymic hyperplasia and mediastinal tumor in patients with Hodgkin's lymphoma after chemotherapy

Tat'yana Nikolaevna Moiseeva; Моисеева Татьяна Николаевна; Lyubov' Sattarovna Al'-Radi; Аль-Ради Любовь Саттаровна; Irina Vadimovna Shitareva; Шитарева Ирина Вадимовна; Aleksandr Abramovich Shevelev; Шевелев Александр Абрамович; Irina Eduardovna Kostina; Костина Ирина Эдуардовна; S K Kravchenko; Кравченко С К; A M Kremenetskaya; Кременецкая A M; N N Tsyba; Цыба Н Н; T N Moiseeva; Moiseeva T N; L S Al-Radi; Al-Radi L S; I V Shitareva; Shitareva I V; A A Shevelev; Shevelev A A; I E Kostina; Kostina I E; S K Kravchenko; Kravchenko S K; A M Kremenetskaya; Kremenetskaya A M; N N Tsyba; Tsyba N N

Differential diagnosis of thymic hyperplasia and mediastinal tumor in patients with Hodgkin's lymphoma after chemotherapy

作者: Moiseeva T.N.¹, Al'-Radi L.S.¹, Shitareva I.V.¹, Shevelev A.A.¹, Kostina I.E.¹, Kravchenko SK¹, Kremenetskaya AM¹, Tsyba NN¹, Moiseeva TN², Al-Radi LS², Shitareva IV², Shevelev AA², Kostina IE², Kravchenko SK², Kremenetskaya AM², Tsyba NN²
隶属关系:
2. Hematological Research Center, Moscow
期: 卷 83, 编号 7 (2011)
页面: 47-50
栏目: Editorial
##submission.dateSubmitted##: 10.04.2020
##submission.datePublished##: 15.07.2011
URL: https://ter-arkhiv.ru/0040-3660/article/view/30882
ID: 30882

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Aim. To make differential diagnosis of thymic hyperplasia and mediastinal tumor after chemotherapy (CT) in patients with Hodgkin's disease (HD).
Material and methods. The examination of 182 HD patients aged 16-71 years (median 28 years) included chest x-ray computed tomography (XCT) at baseline, during treatment, each 3 months, ultrasound investigation of the chest and abdominal cavity. All the patients received 6-8 courses of the treatment according to the program BEACOPP-14 followed by radiotherapy on the residual tumor in 137 patients, or not followed in 45 patients.
Results. Soft tissue tumor in the anterior mediastinum was detected in 14 (31%) from 45 unirradiated patients (age 19-31 years, median 24 years) 1 to 10 months (median 3.5 months) after chemotherapy. The analysis of the data of ultrasound investigation and tomography identified a mediastinal lesion as thymic hyperplasia. The patients are now in remission with follow-up median 21 months (13-36 months). No recurrence was registered.
Conclusion. Young HD patients with unirradiated mediastinum develop thymic hyperplasia in 31% cases within one year after chemotherapy. In view of this, detection of the lesion in the anterior mediastinum after CT demands complex examination for differential diagnosis of thymic hyperplasia with tumor recurrence to avoid unwanted intensification of the treatment.

关键词

lymphogranulomatosis, mediastinum, chemotherapy, thymic hyperplasia

参考

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Differential diagnosis of thymic hyperplasia and mediastinal tumor in patients with Hodgkin's lymphoma after chemotherapy

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详细

关键词

作者简介

Tat'yana Moiseeva

Lyubov' Al'-Radi

Irina Shitareva

Aleksandr Shevelev

Irina Kostina

S Kravchenko

A Kremenetskaya

N Tsyba

T Moiseeva

L Al-Radi

I Shitareva

A Shevelev

I Kostina

S Kravchenko

A Kremenetskaya

N Tsyba

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