Changes in orthogonal ECG in hypertensive patients taking different antihypertensive therapy

Full Text

Abstract

Aim. To ascertain changes in orthogonal ECG in hypertensive patients taking different antihypertensive treatment.
Material and methods. Orthogonal ECG parameters and those of 24-h blood pressure monitoring (BPM) were examined before and after antihypertensive treatment with different drugs in 95 hypertensive patients aged 47±1 years. Of them, 14 patients received trandolapril+verapamil SR for 2 months, 13 patients - candesartan for 3 months, 25 patients - ramipril for 5 months, 26 patients - carvedilol for 4 months, 10 patients - atenolol for 8 months, 7 patients - doxasozine for 5 months.
Results. 24-h BPM parameters improved in all the groups . Initially, conventional ECG evidence on left ventricular hypertrophy was not seen in 86% patients. Dynamics of orthogonal ECG showed that parameters which increase in left ventricular hypertrophy decrease in response to treatment in patients with baseline values above the median. Parameters G and Gx,which in left ventricular hypertrophy diminish, rise significantly in patients with baseline values under median due to therapy. Treatment with impact on renin-angiotensin system reduced voltage parameters of orthogonal ECG, improved G characterizing repolarisation. Treatment with adrenoreceptors blockers reduced IADI.
Conclusion. The analysis of parameters of orthogonal ECG reveals positive dynamics in response to treatment in patients with insignificant changes on ECG in short follow-up. Drugs of different groups change different parameters of orthogonal ECG.

About the authors

Tamara Anatol'evna Sakhnova

Email: blinova@psk-net.ru

Elena Valentinovna Blinova

Email: blinova@psk-net.ru

Galina Vladimirovna Ryabykina

Email: ecg.newtekh@gmail.com

Lyudmila Ivanovna Shutova

Novella Mikhaylovna Chikhladze

Email: novella.cardio@mail.ru

Tamara Vital'evna Martynyuk

Irina Evgen'evna Chazova

T A Sakhnova

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

E V Blinova

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

G V Ryabykina

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

L I Shutova

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

N M Chikhladze

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

T V Martynyuk

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

I E Chazova

Research Cardiology Center, Moscow

Research Cardiology Center, Moscow

References

  1. Bender S. R., Devereux R. B., Okin P. M. Risks of electrocardiographic left ventricular hypertrophy in hypertensive individuals and benefits of treatment-induced regression. Curr. Cardiovasc. Risk Rep. 2009; 3: 247-254.
  2. Блинова Е. В., Сахнова Т. А., Саидова М. А. и др. Информативность показателей ортогональной электрокардиограммы в диагностике гипертрофии левого желудочка. Тер. арх. 2007; 4: 15-18.
  3. Диагностика и лечение артериальной гипертонии. Российские рекомендации (третий пересмотр). М.: РМОАГ, ВНОК; 2008.
  4. Сахнова Т. А., Блинова Е. В., Сергакова Л. М. и др. Возможности использования количественных показателей реполяризации в диагностике гипертрофии левого желудочка у больных артериальной гипертонией. Тер. арх. 2009; 4: 13-17.
  5. Okin P. M., Devereux R. B., Jern S. et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events. J. A. M. A. 2004; 292: 2343-2349.
  6. Verdecchia P., Reboldi G., Angeli F. et al. Prognostic value of serial electrocardiographic voltage and repolarization changes in essential hypertension: the HEART survey study. Am. J. Hypertens. 2007; 20: 997-1004.

Copyright (c) 2011 Sakhnova T.A., Blinova E.V., Ryabykina G.V., Shutova L.I., Chikhladze N.M., Martynyuk T.V., Chazova I.E., Sakhnova T.A., Blinova E.V., Ryabykina G.V., Shutova L.I., Chikhladze N.M., Martynyuk T.V., Chazova I.E.

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Alabyan Street, 13/1, Moscow, 127055, Russian Federation

Managing Editor:

  • Tel.: +7 (926) 905-41-26
  • E-mail: e.gorbacheva@ter-arkhiv.ru

 

© 2018-2021 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies