Long-term effect of 3-week intravenous б-lipoic acid administration in symptomatic diabetic polyneutropathy with clinical manifestations
- Authors: Ametov A.S.1, Novosadova MV1, Barinov AN1, Samigullin R1, Tritschler H.1, Ametov AS2, Novosadova MV2, Barinov AN3, Samigullin R4, Tritschler H-.5
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Affiliations:
- Russian Medical Academy of Postgraduate Education
- Pain Clinic, Marfo-Mariinsk Charity Medical Center
- Orthonica GmbH
- MEDA Pharma GmbH & Co. KG
- Issue: Vol 82, No 12 (2010)
- Pages: 61-64
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30760
Cite item
Full Text
Abstract
Subects and methods. The study included patients with symptoms of myodiabetic polyneuropathy. The authors studied trends in neuropathic symptoms by the TSS scale and neuropathic deficit by the NIS-LL scale after 3-week intravenous a-LA (600 mg/day) administration. Control follow-up visits were made at weeks 8 and 30 of the study.
Results. In б-LA-treated patients, the mean TSS score dropped from 9.46±1.01 to 3.29±1.49 after intravenous б-LA administration and continued to decrease to 2.60±1.18 and 4.39±2.01 scores at follow-up weeks 8 and 30, respectively. In the placebo group, these were 9.78±1.23, 6.16±1.95, 6.52±1.61, and 7.36±1.31 scores at weeks 3, 8, and 30, respectively; p < 0.05). In the б-LA group, NIS-LL scores fell from 8.65±3.46 to 6.01±3.12 at therapy week 3, to 6.11±3.36, at week 8, and to 7.68±3.68 at week 30 and in the placebo group, these decreased from 8.35±3.84 to 7.81±3.51, 7.89±3.72, and 8.32±3.49 scores at weeks 3, and 8, respectively; p < 0.05).
Conclusion. Alleviated neuropathic symptoms persisted within 6 months after 3-week intravenous б-LA injection. Reduced neuropathic deficit did within 8 weeks after initiation of б-LA therapy.
Keywords
About the authors
Aleksandr Sergeevich Ametov
Email: alexander.ametov@gmail.com
M V Novosadova
A N Barinov
R Samigullin
Hans-J'rgen Tritschler
A S Ametov
Russian Medical Academy of Postgraduate EducationRussian Medical Academy of Postgraduate Education
M V Novosadova
Russian Medical Academy of Postgraduate EducationRussian Medical Academy of Postgraduate Education
A N Barinov
Pain Clinic, Marfo-Mariinsk Charity Medical CenterPain Clinic, Marfo-Mariinsk Charity Medical Center
R Samigullin
Orthonica GmbHOrthonica GmbH
H -J Tritschler
MEDA Pharma GmbH & Co. KGMEDA Pharma GmbH & Co. KG
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