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Long-term effect of 3-week intravenous б-lipoic acid administration in symptomatic diabetic polyneutropathy with clinical manifestations
- Authors: Ametov A.S.1, Novosadova MV1, Barinov AN1, Samigullin R1, Tritschler H.1, Ametov AS2, Novosadova MV2, Barinov AN3, Samigullin R4, Tritschler H-.5
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Affiliations:
- Russian Medical Academy of Postgraduate Education
- Pain Clinic, Marfo-Mariinsk Charity Medical Center
- Orthonica GmbH
- MEDA Pharma GmbH & Co. KG
- Issue: Vol 82, No 12 (2010)
- Pages: 61-64
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30760
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Abstract
Subects and methods. The study included patients with symptoms of myodiabetic polyneuropathy. The authors studied trends in neuropathic symptoms by the TSS scale and neuropathic deficit by the NIS-LL scale after 3-week intravenous a-LA (600 mg/day) administration. Control follow-up visits were made at weeks 8 and 30 of the study.
Results. In б-LA-treated patients, the mean TSS score dropped from 9.46±1.01 to 3.29±1.49 after intravenous б-LA administration and continued to decrease to 2.60±1.18 and 4.39±2.01 scores at follow-up weeks 8 and 30, respectively. In the placebo group, these were 9.78±1.23, 6.16±1.95, 6.52±1.61, and 7.36±1.31 scores at weeks 3, 8, and 30, respectively; p < 0.05). In the б-LA group, NIS-LL scores fell from 8.65±3.46 to 6.01±3.12 at therapy week 3, to 6.11±3.36, at week 8, and to 7.68±3.68 at week 30 and in the placebo group, these decreased from 8.35±3.84 to 7.81±3.51, 7.89±3.72, and 8.32±3.49 scores at weeks 3, and 8, respectively; p < 0.05).
Conclusion. Alleviated neuropathic symptoms persisted within 6 months after 3-week intravenous б-LA injection. Reduced neuropathic deficit did within 8 weeks after initiation of б-LA therapy.
Keywords
About the authors
Aleksandr Sergeevich Ametov
Email: alexander.ametov@gmail.com
M V Novosadova
A N Barinov
R Samigullin
Hans-J'rgen Tritschler
A S Ametov
Russian Medical Academy of Postgraduate EducationRussian Medical Academy of Postgraduate Education
M V Novosadova
Russian Medical Academy of Postgraduate EducationRussian Medical Academy of Postgraduate Education
A N Barinov
Pain Clinic, Marfo-Mariinsk Charity Medical CenterPain Clinic, Marfo-Mariinsk Charity Medical Center
R Samigullin
Orthonica GmbHOrthonica GmbH
H -J Tritschler
MEDA Pharma GmbH & Co. KGMEDA Pharma GmbH & Co. KG
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