Behcet's disease and associations with HLA-B5 antigen (a review of literature and the authors' findings)


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Abstract

Aim. To estimate the distribution of HLA Class I (A, B) antigens in patients with Behcet's disease (BD) and the association of HLA-B5 antigen with the clinical manifestations of the disease in different ethnic and population groups in relation to gender.
Subjects and methods. The study covered 93 patients (68 males, 25 females) from the representatives of 24 ethnicities with the verified disease. HLA Class I antigens were typed by the microlymphocytotoxic technique, by applying an antileukocytic serum kit (GISANS, Saint Petersburg).
Results. In patients with BD, the prevalence of HLA-B5 antigen proved to be significantly higher than that in the controls (72.0 and 21%, respectively) and to be similar in patients of different ethnicities living in the Caucasus and Transcaucasus (80-83%) while the number of HLA-B5 antigen-positive patients with BD was thrice less in the Russian population than in other BD patients (p < 0.01). There was a significant correlation of HLA-B5 antigen with ocular lesion (retinal angiitis) predominantly in male patients with BD.
Conclusion. The prevalence of HLA-B5 antigen was higher in patients with BD than in the population-based control. The diagnostic value of this antigen is not so great, for example, in the Russian population of patients with BD. The presence of HLA-B5 antigen in the phenotype of male patients with BD may be regarded as a prognostically poor marker of development of eye diseases.

About the authors

Regina Georgievna Goloeva

Email: regina goloeva@mail.ru

Zemfira Sadullaevna Alekberova

Email: zalekberova@mail.ru

Irina Anatol'evna Guseva

Email: irrgus@yandex.ru

Mikhail Yur'evich Krylov

R G Goloyeva

Research Institute of Rheumatology, Russian Academy of Medical Sciences

Research Institute of Rheumatology, Russian Academy of Medical Sciences

Z S Alekberova

Research Institute of Rheumatology, Russian Academy of Medical Sciences

Research Institute of Rheumatology, Russian Academy of Medical Sciences

I A Guseva

Research Institute of Rheumatology, Russian Academy of Medical Sciences

Research Institute of Rheumatology, Russian Academy of Medical Sciences

M Yu Krylov

Research Institute of Rheumatology, Russian Academy of Medical Sciences

Research Institute of Rheumatology, Russian Academy of Medical Sciences

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