Terapevticheskii arkhivTerapevticheskii arkhivТерапевтический архив0040-36602309-5342LLC Obyedinennaya Redaktsiya30595Editorial articleПередовая статьяBehcet's disease and associations with HLA-B5 antigen (a review of literature and the authors' findings)Болезнь Бехчета и ассоциации с антигеном НLА-В5 (обзор литературы и собственные данные)GoloevaRegina GeorgievnaГолоеваРегина Георгиевна

аспирант; Научно-исследовательский институт ревматологии РАМН

reginagoloeva@mail.ruAlekberovaZemfira SadullaevnaАлекбероваЗемфира Садуллаевна

д-р мед. наук, проф., лаб. системных ревматических заболеваний НИИР РАМН, рук., тел.: 8-499-614-44-52; Научно-исследовательский институт ревматологии РАМН

zalekberova@mail.ruGusevaIrina Anatol'evnaГусеваИрина Анатольевна

канд. мед наук, ст. науч. сотр., лаб. генетики НИИР РАМН, тел.: 8-499-614-44-78; Научно-исследовательский институт ревматологии РАМН

irrgus@yandex.ruKrylovMikhail Yur'evichКрыловМихаил Юрьевич

канд. мед. наук, ст. науч. сотр., лаб. генетики НИИР РАМНтел.: 8-499-614-44-78; Научно-исследовательский институт ревматологии РАМН

GoloyevaR G

Research Institute of Rheumatology, Russian Academy of Medical Sciences

AlekberovaZ S

Research Institute of Rheumatology, Russian Academy of Medical Sciences

GusevaI A

Research Institute of Rheumatology, Russian Academy of Medical Sciences

KrylovM Yu

Research Institute of Rheumatology, Russian Academy of Medical Sciences

Научно-исследовательский институт ревматологии РАМНResearch Institute of Rheumatology, Russian Academy of Medical Sciences15052010825NO5 (2010)ТОМ 82, №5 (2010)454909042020Copyright ©; 2010, Consilium MedicumCopyright ©; 2010, ООО "Консилиум Медикум"2010Consilium MedicumООО "Консилиум Медикум"https://creativecommons.org/licenses/by-nc-sa/4.0https://ter-arkhiv.ru/0040-3660/article/view/30595

Aim. To estimate the distribution of HLA Class I (A, B) antigens in patients with Behcet's disease (BD) and the association of HLA-B5 antigen with the clinical manifestations of the disease in different ethnic and population groups in relation to gender. Subjects and methods. The study covered 93 patients (68 males, 25 females) from the representatives of 24 ethnicities with the verified disease. HLA Class I antigens were typed by the microlymphocytotoxic technique, by applying an antileukocytic serum kit (GISANS, Saint Petersburg). Results. In patients with BD, the prevalence of HLA-B5 antigen proved to be significantly higher than that in the controls (72.0 and 21%, respectively) and to be similar in patients of different ethnicities living in the Caucasus and Transcaucasus (80-83%) while the number of HLA-B5 antigen-positive patients with BD was thrice less in the Russian population than in other BD patients (p < 0.01). There was a significant correlation of HLA-B5 antigen with ocular lesion (retinal angiitis) predominantly in male patients with BD. Conclusion. The prevalence of HLA-B5 antigen was higher in patients with BD than in the population-based control. The diagnostic value of this antigen is not so great, for example, in the Russian population of patients with BD. The presence of HLA-B5 antigen in the phenotype of male patients with BD may be regarded as a prognostically poor marker of development of eye diseases.

Цель исследования. Оценить распределение антигенов НLА класса I (А, В) у больных болезнью Бехчета (ББ) и связь антигена В5 с клиническими проявлениями заболевания в различных этнических и популяционных группах в зависимости от половой принадлежности. Материалы и методы. В исследование включили 93 больных (68 мужчин, 25 женщин) из представителей 24 национальностей с достоверной ББ. Типирование антигенов НLА класса I осуществляли стандартным микролимфоцитотоксическим методом с использованием набора антилейкоцитарных сывороток ("ГИСАНС", Санкт-Петербург). Результаты. Распространенность антигена HLA-В5 у больных ББ оказалась достоверно выше, чем в контроле (72,0 и 21% соответственно) и была сходной у больных разных народностей, проживающих на территории Кавказа и Закавказья (80-83%), в то же время число больных ББ, позитивных по антигену HLA-В5, в русской популяции было в 3 раза меньше, чем у других больных ББ (р < 0,01). Выявлена достоверная корреляция антигена HLA-В5 с поражением глаз (ангиит сетчатки), преимущественно у больных ББ мужского пола. Заключение. Распространенность антигена HLA-В5 у больных ББ достоверно выше, чем в популяционном контроле. Диагностическая значимость этого антигена, например, в русской популяции больных ББ не столь велика. Наличие антигена HLA-В5 в фенотипе больных ББ мужского пола можно рассматривать как прогностически неблагоприятный маркер развития патологии глаз.

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