Phenomenon of hyperexpression of rybosomiccistrons in bone marrow hemopoietic elements in bronchialasthma


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Abstract

Aim. To study expression of ribosomic cistrons (RC) of bone marrow hemopoietic elements (BMHE) in
bronchial asthma (BA).
Material and methods. A total of 37 bronchial asthma (BA) patients were examined. Of them, 20
ones had allergic BA (ABA) and 10 - nonallergic BA (NABA). Seven patients received systemic glucocorticoid
hormones (SGH). Control included cells of bone marrow from 7 healthy donors. Transcription
and maturation of pre-rRNA in BMHE were analysed using bone marrow samples obtained
during the sternal puncture (a modified method of Howell and Black).
Results. RC activity was high. It depended on BA variant and the disease phase. In ABA high RC activity
persisted in remission. GCH suppress RC activity rise. The maximal effect of GCH suppressive
action was seen in myeloid lineage, minimal - in erythroid one. The effect is absent in more mature
erythroid cells and bone marrow lymphocytes.
Conclusion. The phenomenon of RC activity rise in myeloid, erythroid and lymphoid lineages of the
bone marrow of BA patients may reflect contribution of the bone marrow to formation of BA pathogenesis.

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Copyright (c) 2004 Mineev V.N., Mamaev N.N., Ivanovа V.V., Nesterovich I.I., Gindina T.L.

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