Results of midodrin treatment of vasovagal syncope


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Abstract

Aim. To elicit efficacy ofmidodrin in patients with vasovagal syncope.
Material and methods. 50 patients with recurrent vasovagal syncope documented by head-up tilt tests
or bicycle exercise stress tests participated in the study. These tests controlled the effects ofmidodrin if
syncopes occurred again in repetition of the tests. In the other patients the effect of the drug was assessed clinically. All the patients received midodrin in daily dose up to 15 mg.
Results. Mirodrin effectively prevented syncope in 13 (72%) patients as shown by the tilt test, in 10
(59%) patients as shown by the exercise stress tests and in 14 (93%) patients as controlled clinically.
Total efficacy ofmidodrin was 74% (37 of 50 patients).
Conclusion. Midodrin demonstrated high efficacy in prevention of vasovagal syncope. Side effects were
not serious therefore the drug is well tolerated.

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