Cytokine status in patients with chronic obstructive pulmonary disease and its relationships with bone tissue function


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Abstract

Aim. To study cytokine status in patients with chronic obstructive pulmonary disease (COPD) and its interrelations with bone metabolism.
Material and methods. The levels of pro-inflammatory and anti-inflammatory cytokines, bone metabolism markers in the blood were evaluated in 80 patients with COPD.
Results. Changes in cytokine status in COPD patients was established: an increase in pro-inflammatory cytokines and change in anti-inflammatory cytokines. There was hyperproduction of serum proinflammatroy cytokines (IL-lp, IL-6, 1L-8, TNF-a) dependent on FEV1. IL-10 was markedly elevated (p < 0.05) while IL-4 had a trend to elevation (p > 0.05) in patients with COPD. A correlation analysis showed a positive correlation between IL-10, IL-4 and FEV1; IL-10, IL-4 and osteocalcine (bone formation marker), pro-inflammatory cytokines (IL-ip, IL-6 and TNFa) and Crosslaps (bone resorption marker). A negative correlation was discovered between IL-lp, TNFa and body mass index; IL-8 and osteocalcine.
Conclusion. A significant role of cytokine-mediated mechanism in pathogenesis of pulmonogenic osteopenia.

References

  1. Насонов Е. Л., Скрипникова И. А., Насонова В. А. Проблема остеопороза в ревматологии. М.: Стин; 1997.
  2. Насонов Е. Л., Гукасян Д. А., Насонова М. Б. Иммунология ревматоидного артрита и остеопороз: новые данные. Остеопороз и остеопатии 2000; 2: 4-7.
  3. Чучалин А. Г. Хронические обструктивные болезни легких. М.: Бином; 1998.
  4. Hill А. Т., Bayley D., Stockley R. F. The interrelationship of sputum inflammatory markers in patients with chronic bronchitis. Am. J. Respir. Crit. Care Med. 1999; 160: 893-898.
  5. Ershler W. В., Harman S. M., Keller E. T. Immunologic aspects of osteoporosis. Dev. Сотр. Immunol. 1999; 21: 487- 499.
  6. Кочеткова Е. А., Гельцер Б. И. Остеопороз и хроническая обструктивная болезнь легких. Владивосток: Дальнаука; 2003.
  7. Yasuda N., Gotoh К., Minatoguchi S. An increase of soluble Fas, an inhibitor of apoptosis, associated with progression of COPD. Respir. Med. 1998; 92 (8): 993-999.
  8. Taguchi Y., Yamomoto M., Yamate T. InterIeukin-6-type cytokines stimulate mesenchymal progenitor differentiation toward the osteoblastic lineage. Proc. Assoc. Am. Physician 1998; 110: 559-574.
  9. Jilka R. L., Weinstein R. S., Bellido T. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J. Bone Miner. Res. 1998; 13: 793-802.
  10. Wouters E. F. M. Chronic obstructive pulmonary disease: Systemic effects of COPD. Thorax 2002; 57 (12): 1067-1070.
  11. Никитин В. М. Справочник методов биохимической экспресс-индикации микробов. Кишинев: Картя молдовеняска; 1986.
  12. Гриппы М. А. Патофизиология легких. СПб: Бином; 2000.
  13. Rifas L. Bone and cytokines: beyond IL-1, IL-6, and TNF-alpha. Calcif. Tissue Int. 1999; 64: 1-7.
  14. Риггз Б. Л., Мелтон Л. Док. III. Остеопороз: Пер. с англ. М.; СПб: Бином; 2000.
  15. Engelen M. P., Schols A. M., DoelJ. D. et al. Altered glutamate metabolism is associated with reduced muscle glutation levels in patients with emphysema. Am. J. Respir. Cell. Mol. Biol. 2000; 22 (1): 26-33.

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