Effects of p-blockers metoprolol CR/XL andcarvedilol on left ventricular contractility in patients withchronic cardiac failure


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Abstract

Aim. To compare effects of metoproloi CR/XL and carvedilol on global and regional contractility of
the left ventricle in patients with chronic cardiac failure (CCF).
Material and methods. The results of two trials were compared: the effects of metoproloi CR/XL and
on carvedilol left ventricular contractility in patients with chronic cardiac failure (CCF). A total of 52
patients with ischemic heart disease (IHD) and dilated cardiomyopathy (DCMP) entered the studies.
Of them, the treatment was completed in 19 and 20 patients, respectively. Ejection fraction (EF), left
ventricular end systolic and diastolic volumes were measured at radionuclide ventriculography before
and 6 months after the start of the treatment.
Results. Both ^-blockers significantly increased EF and reduced the volumes. In both groups the rise
of contractility in EF < 30% was similar. EF augmentation in patients with DCMP was greater than
that in patients with IHD and depended on improvement of segmental contractility.
Conclusion. Significant differences were not found in the action of two P -blockers on global and regional
contractility of the left ventricle in patients with CCF.

References

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