SYNTHESIS AND ANTIVIRAL ACTIVITY OF COPOLYMERS OF OXYCINNAMIC ACID WITH N-VINYLAMIDES

N. А. Nesterova; Нестерова Н. А.; А. А. Shtro; Штро А. А.; Е. F. Panarin; Панарин Е. Ф.

doi:10.31857/S2686953523600320

SYNTHESIS AND ANTIVIRAL ACTIVITY OF COPOLYMERS OF OXYCINNAMIC ACID WITH N-VINYLAMIDES

Authors: Nesterova N.А.¹, Shtro А.А.², Panarin Е.F.¹
Affiliations:
1. Institute of Macromolecular Compounds, Russian Academy of Sciences
2. Smorodintsev Research Institute of Influenza, Russian Ministry of Health
Issue: Vol 513, No 1 (2023)
Pages: 77-81
Section: CHEMISTRY
URL: https://ter-arkhiv.ru/2686-9535/article/view/651934
DOI: https://doi.org/10.31857/S2686953523600320
EDN: https://elibrary.ru/BJCGOS
ID: 651934

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Abstract
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Abstract

Radical copolymerization of coumarin with N-vinylamides (N‑vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) was used to prepare copolymers of various natures and varied molecular masses. After the subsequent reactions in polymer chains, water-soluble copolymers of salts of oxycinnamic acid and its hydrazides were obtained. The synthesized copolymers of salts and hydrazides of oxycinnamic acid with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).

Keywords

coumarin, copolymers of oxycinnamic acid, N-vinylamides, antiviral activity, hydrazides of oxycinnamic acid

References

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