SYNTHESIS AND ANTIVIRAL ACTIVITY OF COPOLYMERS OF OXYCINNAMIC ACID WITH N-VINYLAMIDES

N. А. Nesterova; Нестерова Н. А.; А. А. Shtro; Штро А. А.; Е. F. Panarin; Панарин Е. Ф.

doi:10.31857/S2686953523600320

SYNTHESIS AND ANTIVIRAL ACTIVITY OF COPOLYMERS OF OXYCINNAMIC ACID WITH N-VINYLAMIDES

Autores: Nesterova N.А.¹, Shtro А.А.², Panarin Е.F.¹
Afiliações:
1. Institute of Macromolecular Compounds, Russian Academy of Sciences
2. Smorodintsev Research Institute of Influenza, Russian Ministry of Health
Edição: Volume 513, Nº 1 (2023)
Páginas: 77-81
Seção: CHEMISTRY
URL: https://ter-arkhiv.ru/2686-9535/article/view/651934
DOI: https://doi.org/10.31857/S2686953523600320
EDN: https://elibrary.ru/BJCGOS
ID: 651934

Citar

Texto integral

Acesso aberto
Acesso é fechado

Acesso está concedido
Acesso é fechado

Somente assinantes

Resumo
Sobre autores
Bibliografia
Arquivos suplementares
Estatísticas

Resumo

Radical copolymerization of coumarin with N-vinylamides (N‑vinylpyrrolidone, N-methyl-N-vinylacetamide, N-vinylformamide) was used to prepare copolymers of various natures and varied molecular masses. After the subsequent reactions in polymer chains, water-soluble copolymers of salts of oxycinnamic acid and its hydrazides were obtained. The synthesized copolymers of salts and hydrazides of oxycinnamic acid with N-vinylamides have low cytotoxicity and demonstrate the pronounced antiviral activity against human respiratory syncytial virus (strain A2).

Palavras-chave

coumarin, copolymers of oxycinnamic acid, N-vinylamides, antiviral activity, hydrazides of oxycinnamic acid

Bibliografia

Anderson R.A., Feathergill K., Diao X., Cooper M., Kirkpatrick R., Spear P., Waller D.P., Chany C., Doncel G.F., Herold B., Lourens J.D., Zaneveld L.J. // J. Androl. 2000. V. 21. № 6. P. 862–875. https://doi.org/10.1002/j.1939-4640.2000.tb03417.x
Schandock F., Riber C.F., Röcker A., Müller J.A., Harms M., Gajda P., Zuwala K., Andersen A.H.F., Løvschall K.B., Tolstrup M., Keppel F., Münch J., Zelikin A.N. // Adv. Healthcare Mater. 2017. V. 6. № 23. 1700748. https://doi.org/10.1002/adhm.201700748
Зарубаев В.В., Бучков Е.В., Назарова О.В., Золотова Ю.И., Панарин Е.Ф. // ДАН. Науки о жизни. 2022. Т. 506. С. 392–395. https://doi.org/10.31857/S2686738922050328
Donalisio M., Ranucci E., Cagno V., Civra A., Manfredi A., Cavalli R., Ferruti P., Lembo D. // Antimicrob. Agents Chemother. 2014. V. 58. № 10. P. 6315–6319. https://doi.org/10.1128/aac.03420-14
Witvrouw M., Fikkert V., Pluymers W., Matthews B., Mardel K., Schols D., Raff J., Debyser Z., De Clercq E., Holan G., Pannecouque C. // Mol. Pharmacol. 2000. V. 58. № 5. P. 1100–1108. https://doi.org/10.1124/mol.58.5.1100
Bianculli R.H., Mase J.D., Schulz M.D. // Macromolecules. 2020. V. 53. № 21. P. 9158–9186. https://doi.org/10.1021/acs.macromol.0c01273
Pachota M., Klysik K., Synowiec A., Ciejka J., Szczubiałka K., Pyrc K., Nowakowska M. // J. Med. Chem. 2017. V. 60. P. 8620–8630. https://doi.org/10.1021/acs.jmedchem.7b01289
Asaftei S., de Clercq E. // J. Med. Chem. 2010. V. 53. № 9. P. 3480–3488. https://doi.org/10.1021/jm100093p
Панарин Е.Ф., Нестерова Н.А., Штро А.А. Сополимеры N-виниламидов с солями оксикоричной кислоты. Патент РФ RU2796753. 2023. Бюл. изобр. № 16.
Niks M., Otto M. // J. Immunol. Methods. 1990. V. 130. № 1. P. 149–151. https://doi.org/10.1016/0022-1759(90)90309-j
Reed L.J., Muench H. // Am. J. Hyg. 1938. V. 27. № 3. P. 493–497. https://doi.org/10.1093/oxfordjournals.aje.a118408
Indrayanto G., Putra G.S., Suhud F. // Profiles of Drug Substances, Excipients and Related Methodology. 2021. V. 46. P. 273–307. https://doi.org/10.1016/bs.podrm.2020.07.005