Synthesis and biological activity of 4-fluorophenylcyclohexyl(tetrahydropyranyl)methyl-substituted aryloxypropanolamines

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By alkylation of 4-fluorophenylacetonitrile with dibrompеntane and 2.2-dichlor-diethylether the corresponding nitriles were obtained, with which reduction by lithium aluminium hydride [1-(4-fluorophenyl)cyclohexyl]- and [1-(4-fluorophenyl)tetrahydro-2 H -pyran-4-yl]methanamines were isolated. By the reaction of the latters with substituted in aromatic cycles aryloxymethyloxiranes new aryloxypropanolamines were been synthesized. Some of them by the action of formaline were transformed to the corresponding oxazolidines.

作者简介

A. Aghekyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru

G. Mkryan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru

G. Melikyan

Yerevan State University

Email: aaghekyan@mail.ru

H. Panosyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru

A. Tsatinyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru

A. Grigoryan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru

H. Gasparyan

The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA

Email: aaghekyan@mail.ru

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