Successful treatment for Hodgkin's lymphoma in a female patient with Ph+ chronic myeloid leukemia


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Abstract

To treat patients with different concurrent cancers, including lympho- and myeloproliferative neoplasms, is a difficult task. The paper presents the experience in successfully treating lymphogranulomatosis occurring in a female patient with chronic myeloid leukemia (CML). A combination of the BEACOPP-14 polychemotherapy regimen and imatinib induced no severe complications. Grade 2 neutropenia requiring no use of granulocyte colony-stimulating factors is the only manifestation of hematological toxicity. Infectious complications were successfully eliminated by first-line antimicrobial therapy in the intercourse periods. Remission in lymphogranulomatosis was achieved by polychemotherapy. The authors conclude that the chosen therapy option is effective and relatively safe in treating patients with CML concurrent with lymphogranulomatosis.

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Успешное лечение лимфомы Ходжкина у больной Ph+ хроническим миелолейкозом. - Аннотация. Лечение больных с сочетанием различных онкологических заболеваний, в том числе лимфо- и миелопролиферативных, является непростой задачей. Приведен опыт успешного лечения лимфогранулематоза, возникшего у пациентки с хроническим миелолейкозом (ХМЛ). Комбинация режима полихимиотерапии BEACOPP-14 и иматиниба не вызвала тяжелых осложнений. Единственным проявлением гематологической токсичности была нейтропения II степени, не потребовавшая применения гранулоцитарных колониестимулирующих факторов. Инфекционные осложнения в межкурсовых периодах успешно купировались противомикробной терапией первого ряда. В результате полихимиотерапии достигнута ремиссия лимфогранулематоза. Авторы делают вывод, что выбранный вариант терапии является эффективным и относительно безопасным у пациентов с сочетанием ХМЛ и лимфогранулематоза.
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