Genetic polymorphisms coding hemostasis protein synthesis and venous thromboembolic complications in Moscow population


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Aim. To estimate incidence of carriage of genetic polymorphisms coding hemostasis protein synthesis in patients with venous thromboembolic complications (VTEC) and healthy subjects in Moscow population; to detect VTEC genetic prognostic factors among the polymorphisms.
Material and methods. A total of 111 patients with the history of deep vein thrombosis and/or pulmonary artery thromboembolism were examined. The control groups consisted of 197 healthy volunteers. Eleven polymorphisms in 7 genes coding hemostasis protein synthesis were investigated: V Leiden G1691A factor, G20210A prothrombin, C677T methylentetrahydrofolatreductase, A1298C methylentetrahydrofolatreductase, type 1 plasminogen activator inhibitor, 4G/5G promoter region, XIII V34L coagulation factor, IIIa L33P thrombocytic glycoprotein, C282Y hemochromatosis, G854A beta-fibrinogen, G455A beta-fibrinogen, C249T beta-fibrinogen.
Results. Polymorphisms of the genes coding hemostasis protein synthesis were detected in all the patients and controls. The carriage occurred with the same frequency, respectively. By one-factor analysis, VTEC was associated with carriage of three heterozygous genotypes: V Leiden factor (p < 0.001), prothrombin (p = 0.052) and hemochromatosis (p = 0.048). Multifactor regression analysis has shown that only carriage of heterozygous polymorphism of V Leiden factor gene is a genetic prognostic factor of VTEC in Moscow population (p = 0.001, RR = 7.00, 95% CI 2.2-21.7).
Conclusion. Genetic polymorphisms coding hemostasis protein synthesis are not a rare finding in Moscow population and occur in all the examinees (both patients and healthy subjects) in different combinations. Only carriage of V Leiden factor heterozygous genotype is a genetic prognostic factor of VTEC in Moscow population and is associated with a 7-fold increase of VTEC risk.

作者简介

Natal'ya Vorob'eva

Email: natalyavorobjeva@mail.ru

Z Khasanova

N Konovalova

A Postnov

Aleksandr Kirienko

Email: phlebo-union@mtu-net.ru

Elizaveta Panchenko

Email: lizapanchenko@mail.ru

N Vorobieva

Russian Cardiological Research Center, Moscow

Russian Cardiological Research Center, Moscow

Z Khasanova

Russian Cardiological Research Center, Moscow

Russian Cardiological Research Center, Moscow

N Konovalova

Russian Cardiological Research Center, Moscow

Russian Cardiological Research Center, Moscow

A Postnov

Russian Cardiological Research Center, Moscow

Russian Cardiological Research Center, Moscow

A Kirienko

N.I. Pirogov Second Russian Medical University, Moscow

N.I. Pirogov Second Russian Medical University, Moscow

E Panchenko

Russian Cardiological Research Center, Moscow

Russian Cardiological Research Center, Moscow

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