Email this article Genetic polymorphisms coding hemostasis protein synthesis and venous thromboembolic complications in Moscow population
- Authors: Vorob'eva N.M.1, Khasanova ZB1, Konovalova NV1, Postnov AY.1, Kirienko A.I.1, Panchenko E.P.1, Vorobieva NM2, Khasanova ZB2, Konovalova NV2, Postnov AY.2, Kirienko AI3, Panchenko EP2
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Affiliations:
- Russian Cardiological Research Center, Moscow
- N.I. Pirogov Second Russian Medical University, Moscow
- Issue: Vol 83, No 3 (2011)
- Pages: 48-52
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30831
- ID: 30831
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Abstract
Material and methods. A total of 111 patients with the history of deep vein thrombosis and/or pulmonary artery thromboembolism were examined. The control groups consisted of 197 healthy volunteers. Eleven polymorphisms in 7 genes coding hemostasis protein synthesis were investigated: V Leiden G1691A factor, G20210A prothrombin, C677T methylentetrahydrofolatreductase, A1298C methylentetrahydrofolatreductase, type 1 plasminogen activator inhibitor, 4G/5G promoter region, XIII V34L coagulation factor, IIIa L33P thrombocytic glycoprotein, C282Y hemochromatosis, G854A beta-fibrinogen, G455A beta-fibrinogen, C249T beta-fibrinogen.
Results. Polymorphisms of the genes coding hemostasis protein synthesis were detected in all the patients and controls. The carriage occurred with the same frequency, respectively. By one-factor analysis, VTEC was associated with carriage of three heterozygous genotypes: V Leiden factor (p < 0.001), prothrombin (p = 0.052) and hemochromatosis (p = 0.048). Multifactor regression analysis has shown that only carriage of heterozygous polymorphism of V Leiden factor gene is a genetic prognostic factor of VTEC in Moscow population (p = 0.001, RR = 7.00, 95% CI 2.2-21.7).
Conclusion. Genetic polymorphisms coding hemostasis protein synthesis are not a rare finding in Moscow population and occur in all the examinees (both patients and healthy subjects) in different combinations. Only carriage of V Leiden factor heterozygous genotype is a genetic prognostic factor of VTEC in Moscow population and is associated with a 7-fold increase of VTEC risk.
About the authors
Natal'ya Mikhaylovna Vorob'eva
Email: natalyavorobjeva@mail.ru
Z B Khasanova
N V Konovalova
A Yu Postnov
Aleksandr Ivanovich Kirienko
Email: phlebo-union@mtu-net.ru
Elizaveta Pavlovna Panchenko
Email: lizapanchenko@mail.ru
N M Vorobieva
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
Z B Khasanova
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
N V Konovalova
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A Yu Postnov
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A I Kirienko
N.I. Pirogov Second Russian Medical University, MoscowN.I. Pirogov Second Russian Medical University, Moscow
E P Panchenko
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
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