Email this article Incidence rate of celiac disease in patients withchronic diarrhea
- Authors: Parfenov AI1, Gudkova RВ1, Krums LM1, Sabelnikova EA1, Chikunova BZ1, Bykova SV1, Firsova LD1, Sivash ES1
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Affiliations:
- Issue: Vol 78, No 9 (2003)
- Pages: 55-60
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/29658
- ID: 29658
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Abstract
Material and methods. Serum levels of IgA-antibodies to gliadin, endomysium, reticulin and tissue
transglutaminase were examined in 206 patients with CD. Biopsies were obtained from a distal portion
of the duodenum or a proximal portion of the jejunum.
Results. CD was diagnosed in 35 (16.9%) of 206 patients with ChD. The disease was typical in 5
(2.4%) patients and was latent in 30 (14.5%) patients. Antibodies to gliadin, endomysium, reticulin
and tissues transglutaminase in diagnostically significant titers were detected in the serum of all the examinees
with CD. Formation of the antitissue antibodies occurred because of destructive-dystrophic alterations
of the connective tissue of the lamina propria mucosae pointing to the autoimmune nature of
a pathological process in celiac disease.
Conclusion. To diagnose CD in ChD patients, it is necessary to supplement standard examination with
duodenobiopsy, tests for antibodies to gliadin, tissue transglutaminase and to tissue structures - endomysium
and reticulin.
About the authors
A I Parfenov
R В Gudkova
L M Krums
E A Sabelnikova
B Z Chikunova
S V Bykova
L D Firsova
E S Sivash
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