T-cell tumors withaplastic syndromes

Aim. To detect and verify the existence of a specific form of T-cell tumor accompanied by isolated lesions
of bone marrow and aplastic syndromes.
Material and methods. Four patients with aplastic syndromes were examined using clinical, histological,
cytological, cytogenetic, and immunophenotypic methods.
Results. Four cases of T-cell tumors of bone marrow with clinical and morphological manifestations of
aplastic syndrome and scanty proliferation activity in bone marrow alone were diagnosed. The proliferation
activity in bone marrow was observed as formation of small clusters composed of small-size
lymphoid cells with dense nucleus. Dynamic monitoring of two patients revealed a trend toward an increase
in the lymphoproliferation base against the remaining clinical picture of aplastic syndrome. The
T-cell immunophenotype characterized by disappearance of some markers or decrease in their density,
was observed only in some blood and bone marrow lymphocytes. The most significant changes of immunophenotype
were observed in one of the patients (CD2+CD3-CD4-CD5-CD7-CD8-CD16-CD56-CD45RO++).
The same patient had pronounced cytogenetic changes (47XY+Y[8J, 47, XY,
del(l)(pl0) [23], 46 XY [3]) and resistance to routine therapy, including cyclosporin. In one patient
the process transformed into lymphosarcoma.
Conclusion. The results obtained in four patients allow their clinicomorphological characteristics to be
regarded as particular forms of T-cell tumors accompanied by bone marrow damage and aplastic syndrome.

aplastic syndrome, T-cell lymphomas, T-cell leukemias, immunophenotype