Trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide in the treatment of chronic heart failure


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Aim. To study trends in systemic inflammatory factors and aminoterminal brain natriuretic propeptide (NT-proBNP) in the blood of patients with stage IIA and IIB chronic heart failure (CHF) during therapy aimed at reducing venous congestion.
Material and methods. The study enrolled 52 patients with postinfarction cardiosclerosis (PICS). Clinical, echocardiographic and laboratory studies were conducted. The levels of TNF-alpha, IL-6, IL-10 and C-reactive protein (CRP) were measured by enzyme immunoassay. The concentration of endotoxin (ET) was estimated by the end-point chromogenic LAL test, that of NT-proBNP - by immunochromotographic assay.
Results. In the patients with CHF, clinical signs of pulmonary venous congestion are associated with a statistically significant increase in the blood levels of TNF-alpha and CRP, those of systemic venous congestion are related to a further rise in TNF-alpha levels and elevation of blood concentrations of NT-proBNP, ET and IL-10. Treatment-related reduction in pulmonary venous congection is associated with a decrease in the levels of TNF-alpha, CRP and IL-6; that in systemic venous congestion - with lower concentrations of NT-proBNP, TNF-alpha and ET.
Conclusion. Specific changes in the levels of systemic inflammatory factors and NT-proBNP were found in patients with CHF in the presence of pulmonary and systemic venous congestion. Treatment aimed at elimination of the latter leads to reduction in the levels of systemic inflammatory factors and NT-proBNP.

About the authors

Elena Nikolaevna Egorova

Email: enegor@mail.ru

Margarita Ivanovna Kuz'mina

Email: doctormi@mail.ru

Vera Vyacheslavovna Mazur

Email: vvmazur@pochta.ru

Mikhail Nikolaevich Kalinkin

Email: mnkalinkin@yahoo.com

Evgeniy Stanislavovich Mazur

Email: esmazur@pochta.ru

E N Egorova

State Medical Academy, Tver

State Medical Academy, Tver

M I Kuzmina

State Medical Academy, Tver

State Medical Academy, Tver

V V Mazur

State Medical Academy, Tver

State Medical Academy, Tver

M N Kalinkin

State Medical Academy, Tver

State Medical Academy, Tver

E S Mazur

State Medical Academy, Tver

State Medical Academy, Tver

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