Myeloid sarcoma of the small bowel with inversion of chromosome 16: a description of 3 clinical cases

Abstract


Myeloid sarcoma (MS) is a rare malignant solid tumor presented with myeloid blast cells showing varying degrees of maturation. MS may have an extramedullary site, precede, or develop simultaneously with the clinical manifestations of acute myeloid leukemia (AML); it may also occur as an AML relapse. Besides AML, MS may be a manifestation of chronic myeloid leukemia or other chronic myeloproliferative diseases. Due to the fact that this disease is rare, the bulk of the literature on MS is presented with single descriptions of retrospective studies and clinical cases. The paper describes 3 cases of MS with inversion of chromosome 16 and small bowel lesion.

Full Text

Миелоидная саркома тонкой кишки с инверсией 16-й хромосомы: описание 3 клинических случаев. - Аннотация. Миелоидная саркома (МС) - редкая злокачественная солидная опухоль, представленная бластными клетками миелоидного происхождения различной степени созревания. МС может иметь любую экстрамедуллярную локализацию, предшествовать или развиваться одновременно с клиническими проявлениями острого миелоидного лейкоза (ОМЛ), она также может возникать как рецидив ОМЛ. Кроме ОМЛ миелоидная саркома может быть проявлением хронического миелоидного лейкоза или других хронических миелопролиферативных заболеваний. Из-за редкости данного заболевания большая часть литературы, связанная с МС, представлена единичными описаниями ретроспективных исследований и клинических случаев. Представляем описание 3 случаев МС с инверсией 16-й хромосомы и поражением тонкой кишки.

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Copyright (c) 2020 Gavrilina O.A., Bariakh E.A., Parovichnikova E.N., Troitskaia V.V., Zvonkov E.E., Kravchenko S.K., Sinitsyna M.N., Obukhova T.N., Gitis M.K., Savchenko V.G.

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