Erectile dysfunction and obesity


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Abstract

The review considers the relationship between obesity and erectile dysfunction (ED). Obesity is associated with the high prevalence of ED; however, the pathophysiological link between these conditions has yet to be adequately investigated. Visceral obesity leads to the enhanced activity of inflammatory responses and, thus, endothelial dysfunction and decreased plasma testosterone levels, which favors the development of hypogonadism and increases the risk of vascular diseases. Endothelial dysfunction and androgen deficiency in turn give rise to ED.

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Эректильная дисфункция и ожирение. - Аннотация. В обзоре рассматривается взаимосвязь ожирения и эректильной дисфункции (ЭД). Ожирение ассоциируется с высокой распространенностью ЭД; однако патофизиологическая связь между данными состояниями еще недостаточно изучена. Висцеральное ожирение приводит к повышению активности воспалительных реакций и, таким образом, к дисфункции эндотелия, снижению уровня тестостерона в плазме, что способствует развитию гипогонадизма и повышает риск появления сосудистой патологии. В свою очередь дисфункция эндотелия и дефицит андрогенов приводят к развитию ЭД.
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About the authors

A S Ametov

M V Stel'makh

Email: mariastel@mail.ru

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