Interpretation of the concentrations of procalcitonin during infectious and inflammatory processes


The paper analyzes the most important clinical studies dealing with the measurement of procalcitonin concentrations in patients with lower respiratory tract infections or sepsis. Procalcitonin is a marker of bacterial infection, which is successfully used for diagnosis and antimicrobial therapy monitoring in patients with pneumonia or in septic states. The review presents the latest algorithms for interpreting the concentrations of procalcitonin in clinical practice.

Full Text

Интерпретация значений концентрации прокальцитонина при инфекционных воспалительных процессах. - Аннотация. В статье анализируются наиболее значимые в клиническом аспекте исследования, посвященные измерению концентраций прокальцитонина у больных с инфекциями нижних дыхательных путей или сепсисом. Прокальцитонин - маркер бактериальной инфекции, успешно применяемый для диагностики и контроля антимикробной терапии у больных пневмонией или при септических состояниях. В обзоре приводятся последние алгоритмы интерпретации значений концентрации прокальцитонина в клинической практике.


  1. Le Moullec J.M., Jullienne A., Chenais J. et al. The complete sequence of human preprocalcitonin. FEBS Lett 1984; 167 (1): 93-97.
  2. Assicot M., Gendrel D., Carsin H. et al. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet 1993; 341 (8844): 515-518.
  3. Dahaba A.A., Metzler H. Procalcitonin's role in the sepsis cascade. Is procalcitonin a sepsis marker or mediator? Minerva Anestesiol 2009; 75 (7-8): 447-452.
  4. Graber M.A., Dachs R., Darby-Stewart A. Usefulness of procalcitonin measurement in reducing antibiotic use and identifying serious bacterial illness. Am Fam Physician 2011; 84 (2): 177-179.
  5. Müller F., Christ-Crain M., Bregenzer T. et al. Procalcitonin levels predict bacteremia in patients with community-acquired pneumonia: a prospective cohort trial. Chest 2010; 138 (1): 121-129.
  6. Schuetz P., Albrich W., Mueller B. Procalcitonin for diagnosis of infection and guide to antibiotic decisions: past, present and future. BMC Med 2011; 9: 107.
  7. Becker K.L., Nylén E.S., White J.C. et al. Clinical review 167: Procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab 2004; 89 (4): 1512-1525.
  8. Müller B., Peri G., Doni A. et al. High circulating levels of the IL-1 type II decoy receptor in critically ill patients with sepsis: association of high decoy receptor levels with glucocorticoid administration. J Leukoc Biol 2002; 72 (4): 643-649.
  9. Schuetz P., Christ-Crain M., Thomann R. et al. Effect of procalcitonin-based guidelines vs standard guidelines on antibiotic use in lower respiratory tract infections: the ProHOSP randomized controlled trial. JAMA 2009; 302 (10): 1059-1066.
  10. Bone R.C., Balk R.A., Cerra F.B. et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine - 1992. Chest 2009; 136 (5 Suppl): e28.
  11. Uusitalo-Seppälä R., Koskinen P., Leino A. et al. Early detection of severe sepsis in the emergency room: Diagnostic value of plasma C-reactive protein, procalcitonin, and interleukin-6. Scand J Infect Dis 2011; 43 (11-12): 883-890.
  12. Sinha M., Desai S., Mantri S., Kulkarni A. Procalcitonin as an adjunctive biomarker in sepsis. Indian J Anaesth 2011; 55 (3): 266-270.
  13. Schuetz P., Chiappa V., Briel M., Greenwald J.L. Procalcitonin algorithms for antibiotic therapy decisions: a systematic review of randomized controlled trials and recommendations for clinical algorithms. Arch Intern Med 2011; 171 (15): 1322-1331.
  14. Andrejaitiene J., Sirvinskas E., Zebrauskiene I. Procalcitonin: a new infection marker. Its use in intensive care. Medicina (Kaunas) 2002; 38 (5): 491-498.
  15. Meisner M., Adina H., Schmidt J. Correlation of procalcitonin and C-reactive protein to inflammation, complications, and outcome during the intensive care unit course of multiple-trauma patients. Crit Care 2006;10 (1): R1.
  16. Meisner M., Tschaikowsky K., Hutzler A. et al. Postoperative plasma concentrations of procalcitonin after different types of surgery. Intensive Care Med 1998; 24 (7): 680-684.
  17. Park J.H., Wee J.H., Choi S.P., Oh S.H. The value of procalcitonin level in community-acquired pneumonia in the ED. Am J Emerg Med 2012; 30 (7): 1248-1254.



Abstract - 81


Article Metrics

Metrics Loading ...


  • There are currently no refbacks.

Copyright (c) 2012 Piatnitskiĭ I.A., Sharandak A.P., Zokina T.G., Berner L.P.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Novoslobodskaya str 31c4., Moscow, 127005, Russian Federation

Managing Editor:


© 2018 "Consilium Medicum" Publishing house

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies