Email this article A histological response to antiviral therapy for chronic hepatitis C in patients who failed to achieve a sustained virological response
- Authors: Riumin AM1, Korochkina OV1
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Affiliations:
- Issue: Vol 84, No 11 (2012)
- Pages: 59-60
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/31139
- ID: 31139
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Abstract
The paper presents the results of combination antiviral therapy (AVT) in 2 patients with chronic hepatitis C (CHC) unresponsive to AVT. Both patients are classified as difficult to treat (genotype 1b, a high viral load, overweight). 1.5 years after the termination of a course of AVT, histological examination of biopsy specimens revealed a histological response in one patient and significant histological worsening in the other. The specific features of the development of a histological response to AVT and possible reasons for its lack are discussed by the example of the described patients.
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Гистологический ответ на противовирусную терапию хронического гепатита С у пациентов, не достигших устойчивого вирусологического ответа. - Аннотация. Представлено клиническое наблюдение результатов комбинированной противовирусной терапии (ПВТ) у 2 больных хроническим гепатитом С (ХГС), не ответивших на ПВТ. Оба больных относятся к категории "трудных" для лечения (генотип 1b, высокая вирусная нагрузка, избыточная масса тела). Через 1,5 года после окончания курса ПВТ при гистологическом исследовании биоптатов выявлены гистологический ответ у одного больного и значительное гистологическое ухудшение у другого. На примере описанных больных обсуждаются особенности развития гистологического ответа на ПВТ и возможные причины его отсутствия.×
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