Hepatitis C virus Genotype 3: that "simple", yet that "complex"


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Abstract

The data on natural course of chronic viral hepatitis C infection (HCV) and the efficacy of antiviral treatment depending on virus genotype are summarized in the article. The significance of virus genotype in progression of liver febrosis and liver steatosis is discussed. It is pointed out that chronic HCV infection caused by genotype 3 is characterized by a more aggressive clinical course of disease and less favorable prognosis. Optimal approaches to the management of patients with genotype 3 of chronic HCV infection as well as perspectives of antiviral therapy in this group of patients are discussed in the article.

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Вирус гепатита С 3-го генотипа: такой "простой", такой "сложный". - Аннотация. Представлены данные о естественном течении и эффективности терапии хронического гепатита С, вызванного вирусами различных генотипов. Обсуждается роль генотипа вируса в прогрессировании фиброза и формировании стеатоза печени. Отмечается, что хронический гепатит С, вызванный вирусом 3-го генотипа, характеризуется более агрессивным течением и менее благоприятным прогнозом. Определены оптимальные подходы к ведению больных хроническим гепатитом С, вызванного вирусом 3-го генотипа, а также перспективы противовирусной терапии у пациентов данной категории.
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