Email this article Determination of subepithelial deposits of IgA antibodies to tissue transglutaminase: practical experience with application for diagnosis of gluten-sensitive celiac disease
- Authors: Vokhmyanina N.V.1, Kozlov AV1, Parfenov A.I.1, Oreshko L.S.1, Vokhmyanina NV2, Kozlov AV3, Parfenov AI4, Oreshko LS5
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Affiliations:
- Medicogenetic Diagnostic Center, Moscow
- Medical Academy of Postgraduate Education, St-Peterburg
- Central Research Institute of Gastroenterology, Moscow
- I.I. Mechnikov St-Petersburg State Medical Academy
- Issue: Vol 84, No 2 (2012)
- Pages: 26-30
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30981
- ID: 30981
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Abstract
Material and methods. Enzyme immunoassay examined IGA-tTG deposits after their isolation from biopsy specimens of small intestinal mucosa of 53 patients with GSCD and 45 control patients.
Results. Elevated levels of IGA-tTG deposits were found in 98% patients with GSCD. This elevation in the controls occurred in patients with autoimmune pathology and in patients with such levels of the serum markers which were in the range of reference limits in the absence of GSCD morphometric characteristics in biopsy specimen but with verified diagnosis celiac disease.
Conclusion. This method showed high diagnostic efficacy in detection of subepithelial IGA-tTG deposits for diagnosis of GSCD and monitoring of pathogenetic diet therapy.
About the authors
Natal'ya Vasil'evna Vokhmyanina
Email: spbnat@yandex.ru
A V Kozlov
Asfol'd Ivanovich Parfenov
Email: asfold@mail.ru
Lyudmila Savarbekovna Oreshko
Email: oreshko@yandex.ru
N V Vokhmyanina
Medicogenetic Diagnostic Center, MoscowMedicogenetic Diagnostic Center, Moscow
A V Kozlov
Medical Academy of Postgraduate Education, St-PeterburgMedical Academy of Postgraduate Education, St-Peterburg
A I Parfenov
Central Research Institute of Gastroenterology, MoscowCentral Research Institute of Gastroenterology, Moscow
L S Oreshko
I.I. Mechnikov St-Petersburg State Medical AcademyI.I. Mechnikov St-Petersburg State Medical Academy
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