Email this article Specific features of lymphoid infiltration in liver biopsy in patients with chronic viral hepatitis B and C
- Authors: Umbetova K.T.1, Lazareva A.S.1, Kiselevskiy M.V.1, Parkhomenko Y.G.1, Volchkova E.V.1, Pak S.G.1, Umbetova KT2, Lazareva AS2, Kiselevsky MV3, Parkhomenko Y.G4, Volchkova EV2, Pak SG2
-
Affiliations:
- I.M. Sechenov First Moscow State University
- N.N. Blokhin Cancer Research Center, Moscow
- Infection hospital N 2, Moscow
- Issue: Vol 83, No 11 (2011)
- Pages: 31-33
- Section: Editorial
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30928
- ID: 30928
Cite item
Full Text
Abstract
Material and methods. The examination of 37 patients with CVHB (n = 13) and CVHC (n = 24) included liver puncture biopsy by Mengini, subsequent histological and morphological investigation of liver biopsy with immunohisto- and immunocytochemistry.
Results. In CVHB and CVHC patients leukocytic infiltrates (LI) of the liver present primarily with T-lymphocytes (CD3+), NKT cells (CD3+CD16+CD56+), NK cells (CD16+CD56+), T-regulatory lymphocytes (CD4+CD25+), cytotoxic T-lymphocytes (CD8+). Cytotoxic lymphocytes (CD8+) and NK cells (CD16+CD56+) detected in hepatic LI of patients with chronic viral hepatitis are similar in composition with cells in hepatic tissue infiltrates in autoimmune hepatitis. We are the first to detect the complex of T-regulatory cells (CD4+CD25+)in hepatic parenchyma of these patients. This complex suppresses cellular immune response in virus elimination and damaged tissues and supports development of persistent viral infection with autoimmune component.
Conclusion. The complex of T-regulatory cells (CD4+CD25+) isolated in hepatic LI evidences for existence of a morphofunctional base for autoimmune manifestations in the presence of persistent viral infection.
About the authors
Karina Turakbaevna Umbetova
Email: karinasara@inbox.ru
Anna Svyatoslavovna Lazareva
Mikhail Valentinovich Kiselevskiy
Yuriy Georgievich Parkhomenko
Elena Vasil'evna Volchkova
Sergey Grigor'evich Pak
K T Umbetova
I.M. Sechenov First Moscow State UniversityI.M. Sechenov First Moscow State University
A S Lazareva
I.M. Sechenov First Moscow State UniversityI.M. Sechenov First Moscow State University
M V Kiselevsky
N.N. Blokhin Cancer Research Center, MoscowN.N. Blokhin Cancer Research Center, Moscow
Yu G Parkhomenko
Infection hospital N 2, MoscowInfection hospital N 2, Moscow
E V Volchkova
I.M. Sechenov First Moscow State UniversityI.M. Sechenov First Moscow State University
S G Pak
I.M. Sechenov First Moscow State UniversityI.M. Sechenov First Moscow State University
References
- Скляр Л. Ф., Никифоров Н. Д., Маркелова Е. В. и др. Цитокиновый профиль при хроническом гепатите С. Клин. мед. 2005; 10: 40-44.
- Gramenzi A., Andreone P., Loggi E. Cytokine profile of peripheral blood mononuclear cells from patients with different outcomes of hepatitis С virus infection. J. Viral Hepat. 2005; 12 (5): 525-530.
- Лазарева А. С., Волчкова Е. В., Умбетова К. Т. и др. Особенности цитокинового профиля и субпопуляционного состава лимфоцитов периферической крови у больных хроническими вирусными гепатитами В и С в сопоставлении с выраженностью морфологических изменений печени. Тер. арх. 2009; 11: 55-60.
- Апросина З. Г., Серов В. В. Хронические вирусные заболевания печени; пато- и морфогенез, клиническая характеристика. Тер. арх. 1995; 5: 77-80.
- Cecere A., Marotta F., Vangieri В. et al. Progressive liver injury in chronic hepatitis С infection is related to altered cellular immune response and to different citokine profile. Panminerva Med. 2004; 46 (3): 171-187.
- Чепель Э., Хейни М., Мисбах С., Сновден Н. Основы клинической иммунологии. М.: ГЭОТАР-Медиа; 2008.
- Апросина З. Г. Аутоиммунный гепатит. Гепат. форум. 2009; 1: 4-9.
- Kondo Y., Kobayashi K., Ueno Y. et al. Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B. Wld J. Gastroenterol. 2006; 12 (27): 4310-4317.
Supplementary files
