Incidence of solid tumors in patients with chronic lymphocytic leukemia exposed to radiation after Chernobyl accident

Abstract


Aim. To study incidence of solid tumors in patients who developed chronic lymphocytic leukemia (CLL) after exposure to ionizing radiation after the Chernobyl accident.
Material and methods. After analysis of data on all CLL male patients living in Kiev registered in the National Cancer Register of Ukraine in 1991-2008, these patients were divided into two groups. Group 1 consisted of 56 Chernobyl rescuers exposed to ionizing radiation, group 2 - of 684 patients without history of Chernobyl-related radiation.
Results. Solid tumors were detected in 14 cases in group 1 and 74 cases in group 2 (p = 0.001). Risk to develop solid tumors in group 1 was significantly higher (OR 3.29 in 95% CI from 1.61 to 6.62).
Conclusion. The conclusion made needs further verification on wider data base.

About the authors

Irina Viktorovna Abramenko

Email: nbilous@yahoo.com

Nadezhda Ivanovna Belous

Email: nbilous@yahoo.com

Irina Anatol'evna Kryachok

Email: ipn3411@i.com.ua

Zoya Vladimirovna Martina

Email: zosyamed@mail.ru

Natal'ya Anatol'evna Gudzenko

Email: gudznat@gmail.comовна

Zoya Pavlovna Fedorenko

Email: root@ucr@kiev.ua

Lyubov' Borisovna Kutsenko

Email: root@ucr@kiev.ua

Irina Sergeevna Dyagil'

Email: dyagil@mail.ru

Anatoliy Andreevich Chumak

Email: papatolia@mail.ru

Dmitriy Anatol'evich Bazyka

Email: bazyka@rcrm.kiev.ua

Vladimir Grigor'evich Bebeshko

Email: bebeshko@rcrm.kiev.ua

I V Abramenko

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

N I Belous

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

I A Kryachok

National Cancer Institute, Kiev, Ukraine

National Cancer Institute, Kiev, Ukraine

Z V Martina

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

N A Gudzenko

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Z P Fedorenko

National Cancer Institute, Kiev, Ukraine

National Cancer Institute, Kiev, Ukraine

L B Kutsenko

National Cancer Institute, Kiev, Ukraine

National Cancer Institute, Kiev, Ukraine

I S Dyagil

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

A A Chumak

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

D A Bazyka

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

V G Bebeshko

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

Radiation Medicine Research Center, Institute of Clinical Radiology, Kiev, Ukraine

References

  1. Davis J. W., Weiss N. S., Armstrong B. K. Second cancers in patients with chronic lymphocytic leukemia. J. Natl. Cancer Inst. 1987; 78(1): 91-94.
  2. Travis L. B., Curtis R. E., Hankey B. F., Fraumeni J. F. Second cancers in patients with chronic lymphocytic leukemia. J. Natl. Cancer Inst. 1992; 84 (18): 1422 - 1427.
  3. Hisada M., Biggar R. J., Greene M. H. et al. Solid tumors after chronic lymphocytic leukemia. Blood 2001; 98(6): 1979-1981.
  4. Wiernik P. H. Second neoplasms in patients with chronic lymphocytic leukemia. Curr. Treat. Options Oncol. 2004; 5(3): 215-223.
  5. Tsimbericbu A. M., Wen S., McLaughlin P. et al. Other malignancies in chronic lymphocytic leukemia/small lymphocytic lymphoma. J. Clin. Oncol. 2009; 27(6): 904-910.
  6. Полищук O. H. Клинико-гематологические особенности и тактика лечения В-клеточной хронической лимфоцитарной лейкемии у участников ликвидации последствий аварии на Чернобыльской АЭС 1986-1987 гг.: Автореф. дис. ... канд. мед. наук. Киев; 2005.
  7. Abramenko I., Bilous N., Chumak A. et al. Chronic lymphocytic leukemia patients exposed to ionizing radiation due to the Chernobyl NPP accident - with focus on immunoglobulin heavy chain gene analysis. Leukemia Res. 2008; 32(4): 535-452.
  8. Глузман Д. Ф., Скляренко Л. М., Абраменко И. В. и др. 7-летний опыт работы Референтной лаборатории по диагностике онкогематологических заболеваний. Онкология 2000; 2(1-2): 91-93.
  9. Чумак А. А., Базыка Д. А., Талько В. В. Клинические иммунологические исследования в радиационной медицине - пятнадцатилетний опыт. Укр. журн. гематол. и трансфузиол. 2002; 5: 6-11.
  10. Дягиль И. С., Гудзенко Н. А., Клименко В. И. и др. Опыт проведения международной гематологической экспертизы в Украине. Укр. журн. гематол. и трансфузиол. 2001; 1: 15-19.
  11. Sawka A. M., Thabane L., Parlea L. et al. Second primary malignancy risk afted radioactive iodine treatment for thyroid cancer: a systematic review and meta-analysis. Thyroid 2009; 19(5): 451-457.
  12. Kaatsch P., Reinisch I., Spix C. et al. Case-control study on the therapy of childhood cancer and the occurrence of second malignant neoplasms in Germany. Cancer Causes Control 2009; 20(6): 965-980.
  13. Ellis M., Lishner M. Second malignancies following treatment in non-Hodgkin's lymphoma. Leukemia and Lymphoma 1993; 9(4): 337-342.
  14. Little M. P. Cancer and non-cancer effects in Japanese atomic bomb survivors. J. Radiol. Prot. 2009; 29(2a): 43-59.
  15. Romanenko A. Y., Finch S. C., Hatch M. et al. The Ukrainian-American study of leukemia and related disorders among Chornobyl cleanup workers from Ukraine: III. Radiation risks. Radiat. Res. 2008; 170(6): 711-720.
  16. Prysyazhnyuk A., Gristchenko V., Fedorenko Z. et al. Twenty years after the Chernobyl accident: solid cancer incidence in various groups of the Ukrainian populations. Radiat. Environ. Biophys. 2007; 46(1): 43-51.
  17. Williams D. Radiation carcinogenesis: lessons from Chernobyl. Oncogene 2008; Suppl. 2: 59-68.
  18. Linet M. S., Cartwright R. A. The leukemias. In: Schottenfeld D., Fraumeni J. R., eds. Cancer epidemiology and Prevention. 2-nd ed. New York: Oxford University Press; 1996: 841-892.
  19. Chumak A., Bazyka D., Beliaeva N. et al. Immunological effects in acute radiation sickness reconvalescents - results of thirteen years of follow-up. Int. J. Radiat. Med. 2000; 1: 65- 83.
  20. Kuzmenok O., Potapnev M., Potapova S. et al. Late effects of the Chernobyl radiation accident on T cell-mediated immunity in cleanup workers. Radiat. Res. 2003; 169(1): 109-116.

Statistics

Views

Abstract - 119

Cited-By


Article Metrics

Metrics Loading ...

Refbacks

  • There are currently no refbacks.

Copyright (c) 2011 Abramenko I.V., Belous N.I., Kryachok I.A., Martina Z.V., Gudzenko N.A., Fedorenko Z.P., Kutsenko L.B., Dyagil' I.S., Chumak A.A., Bazyka D.A., Bebeshko V.G., Abramenko I.V., Belous N.I., Kryachok I.A., Martina Z.V., Gudzenko N.A., Fedorenko Z.P., Kutsenko L.B., Dyagil I.S., Chumak A.A., Bazyka D.A., Bebeshko V.G.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.
 

Address of the Editorial Office:

  • Novij Zykovskij proezd, 3, 40, Moscow, 125167

Correspondence address:

  • Novoslobodskaya str 31c4., Moscow, 127005, Russian Federation

Managing Editor:

 

© 2018 "Consilium Medicum" Publishing house


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies