Email this article Prolongation of enoxaparin therapy to one month promotes recanalization of occlusively thrombosed deep veins
- Authors: Vorob'eva N.M.1, Panchenko E.P.1, Ermolina O.V.1, Balakhonova T.V.1, Dobrovol'skiy A.B.1, Titaeva E.V.1, Khasanova Z.B.1, Postnov A.Y.1, Kirienko A.I.1, Vorobyeva NM2, Panchenko EP2, Ermolina OV2, Balakhonova TV2, Dobrovolsky AB2, Titaeva EV2, Khasanova ZB2, Postnov AY.2, Kirienko AI3
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Affiliations:
- Russian Cardiological Research Center, Moscow
- N.I. Pirogov Russian State Medical University, Moscow
- Issue: Vol 83, No 8 (2011)
- Pages: 33-37
- Section: Editorial
- Submitted: 10.04.2020
- Published: 15.08.2011
- URL: https://ter-arkhiv.ru/0040-3660/article/view/30885
- ID: 30885
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Abstract
Material and methods. Thirty patients were selected from 111 patients with a history of deep vein thrombosis (DVT) and/or pulmonary artery embolism according to the following criteria: the presence of occlusive thrombosis of one deep vein minimum; the absence of DVT for 12 months of follow-up. Patients of group 1 (n = 15) received standard therapy (UFH for at least 5 days) with switch to warfarin. Patients of group 2 (n = 15) received therapeutic doses of enoxaparin (1 mg/kg each 12 hours) for 30 days minimum with switch to warfarin. Follow-up was 12 months. Ultrasonic duplex angioscanning of the limbs was made at baseline, 1, 3, 6 and 12 months after treatment start.
Results. After follow-up month 1, 3 and 6 number of patients with occlusive DVT was significantly less in group 2. All the patients given enoxaparin achieved recanalization of OTDV within 3 months of treatment. OTDV recanalization was not achieved in 20% patients of group 1 even 12 months after treatment start.
Conclusion. Prolongation of enoxaparin treatment to 1 month followed by warfarin treatment is superior to standard UFH treatment followed by warfarin in providing recanalization of OTDV within 3 months of treatment. Moreover, this treatment predicts persistence of recanalization within 12 months of anticoagulant therapy.
About the authors
Natal'ya Mikhaylovna Vorob'eva
Email: natalyavorobjeva@mail.ru
Elizaveta Pavlovna Panchenko
Email: lizapanchenko@mail.ru
Ol'ga Vladimirovna Ermolina
Email: olyak65@yandex.ru
Tat'yana Valentinovna Balakhonova
Email: tvbdoc@gmail.ru
Anatoliy Borisovich Dobrovol'skiy
Email: abdobrovolsky@inbox.ru
Elena Vladimirovna Titaeva
Email: evlti@mail.ru
Zukhra Bilyalovna Khasanova
Email: khasanova@mail.ru
Anton Yuvenal'evich Postnov
Email: a.postnov@mail.ru
Aleksandr Ivanovich Kirienko
Email: phlebo-union@mtu-net.ru
N M Vorobyeva
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
E P Panchenko
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
O V Ermolina
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
T V Balakhonova
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A B Dobrovolsky
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
E V Titaeva
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
Z B Khasanova
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A Yu Postnov
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A I Kirienko
N.I. Pirogov Russian State Medical University, MoscowN.I. Pirogov Russian State Medical University, Moscow
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