Transplantation of hemopoietic stem cells in autoimmune diseases


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Abstract

Transplantation of stem hemopoietic cells is a new trend in the treatment of some autoimmune diseases.Large international trials made in the last 12 years in the USA, Europe, Russia, China were devoted to evaluation of efficacy of this method. Basing on the results of these trials, experts of the Russian Cooperative Cell Therapy Group and N.I. Pirogov National Medicosurgical Center have developed a conception of high-dose immunosuppressive therapy with transplantation of stem hemopoietic cells in autoimmune diseases. Main positions of the conception and its perspectives are discussed.

About the authors

Andrey Arkad'evich Novik

Email: ncrtc04@mail.ru

A A Novik

N.I. Pirogov National Medicosurgical Center, Institute of Advanced Medical Training

N.I. Pirogov National Medicosurgical Center, Institute of Advanced Medical Training

References

  1. Cruse J. M., Lewis R. E., eds. Clinical and molecular aspects of autoimmune diseases. Basel; Sydney: Karger, 1992.
  2. Hoffman ed. Hematology: Basic principles and practice. 3nd ed. - New York et al.: Churcill Livingston, 2000.
  3. Sullivan K. M. Long term follow-up and quality of life after hematopoetic stem cell transplantation. J. Rheumatol. 1997; 48(suppl.): 46-52.
  4. Connors J. M., Reece D., Diehl V. et al. Hodgkin's lymphoma: New approaches to treatment. Hematology 1998: 274-295.
  5. Новик А. А., Богданов А. Н. Принципы трансплантации костного мозга и стволовых клеток периферисеской крови. СПб.: Военно-медицинская академия, 2001.
  6. Euler H. H., Marmont A. M., Bacigalupo A. et al. Early recurrence of persistence of autoimmune diseases after unmanipulated autologous stem cell transplantation. Blood 1996; 88(11): 3621-3625.
  7. Sullivan K. M., Nelson J. L., Arnason B. G. W. et al. Evolving role of hematopoietic stem cell transplantation in autoimmune disease. Hematology 1998: 198-214.
  8. Tyndal A., Black C., Fince J. et al. Treatment of systemic sclerosis with autologous haemopoietic stem cell transplantation. Lancet 1997; 349: 254.
  9. Saccardi R., Mancardi G., Bacigalupo A. et al. Autologous hematopoietic stem cell transplantation in secondary progressive MS; clinical, MRI and laboratory findings. Bone Marrow Transplant. 2002; 29(suppl. 2): 13.
  10. Snowden J., Moore J., Passweg S. et al. Autologous hematopoietic stem cell transplantation in rheumatoid arthritis (RA): a report from the EBMT and IBMTR. Bone Marrow Transplant. 2002; 29(suppl. 2): 14.
  11. Cualandi F., Bacigalupo A., Lint M. T. et al. Relapsing/refractory Evans-syndrome treated with reduced intensity allogenic HLA-identical bone marrow transplantation. Bone Marrow Transplant. 2002; 29(suppl. 2): 14.
  12. Новик А. А. Трансплантация стволовых кроветворных клеток при аутоиммунных заболеваниях. Вестн. Рос. Воен.-мед. акад. 2002; 7(1): 98-102.
  13. Zhao X., Fu Y., Peng X. Autologous hematopoietic stem cell transplantation in the treatment of systemic lupus erithematosus. Bone Marrow Transplant. 2002; 29(suppl. 2): 15.
  14. Marmont A. M. Hematopoietic stem cell transplantation in autoimmune diseases. Autoimmunity 2008; 41: 556-690.
  15. Marmont A. M. Will hematopoietic stem cell transplantation cure human autoimmune disease? Autoimmunity 2008; 30: 145-150.
  16. Annaloro C., Onida F., Deliliers G. L. Autologous hematopoietic stem cell transplantation in autoimmune diseases. Expert Rev. Hematol. 2009; 2(6): 699-715.
  17. Farge D., Labopin M., Tyndall A. et al. Autologous hematopoietic stem cell transplantation (HSCT) for autoimmune diseases: an observational study on 12 years of experience from the European Group for Blood and Marrow Transplantation (EBMT) Working Party on Autoimmune Diseases. Haematologica 2009; 95(2): 284-292. doi: 10.3324/haematol.2009.013458.
  18. Shevchenko Y., Novik A., Ionova T. et al. Quality of life as a new paradigm to assess outcomes of high dose therapy and autologous stem cell transplantation in multiple sclerosis patients. Hematol. J. 2003; 4(suppl. 2): 78.
  19. Новик А. А., Ионова Т. И., Кайнд П. Концепция исследования качества жизни в медицине. СПб.: ЭЛБИ, 1999.

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