B-cell lymphoma in a woman with chronic hepatitis C and mixed cryoglobulinemia of type 2


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Abstract

A report is presented of a rare case of B-cell non-Hodgkin"s lymphoma and severe exacerbation of cryoglobulinic vasculitis which developed in a female patient with chronic hepatitis C four years after achievement of a persistent virusological response to antivirus treatment. Causes of a specific course of the disease and development of the tumor in the absence of HCV in blood serum are discussed: latent HCV-infection in immune cells with persistent antigenic stimulation of B-lymphocytes, possibility of HCV-independent lymphoproliferation.

About the authors

Tat'yana Mikhaylovna Ignatova

Email: tmignatova@newmail.ru

Svetlana Yur'evna Milovanova

Ol'ga Alekseevna Chernova

Zhazira Zhambulatovna Bayzhanova

T M Ignatova

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

S Yu Milovanova

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

O A Chernova

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

Zh Zh Baizhanova

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

References

  1. Игнатова Т. М., Серов В. В., Мухин Н. А. и др. HCV-инфекция и смешанная криоглобулинемия. Клин. мед. 2005; 6: 37-43.
  2. Козловская Л. В., Гордовская Н. Б., Малышко Е. Ю. и др. Клиническое значение смешанной криоглобулинемии. Рос. мед. журн. 2003; 4: 11-15.
  3. Charles E. D., Dustin L. B. Hepatitis C virus-induced cryoglobulinemia. Kidney Int. 2009; 76 (8): 818-824.
  4. Zignego A. L., Giannini C., Monti M., Gragnani L. Hepatitis C virus lymphotropism: lessons from a decade of studies. Dig. Liver Dis. 2007; 39 (suppl. 1): S38-S45.
  5. Kelaidi C., Rollot F., Park S. et al. Response to antiviral treatment in hepatitis C virus-associated marginal zone lymphomas. Leukemia 2004; 18: 1711-1716.
  6. Casato M., Lilli D., Donato G. et al. Occult hepatitis C virus infection in type II mixed cryoglobulinaemia. J. Viral Hepatit. 2003; 10 (6): 455-459.
  7. Levine J. W., Gota C., Fessler B. J. et al. Persistent cryoglobulinemic vasculitis following successful treatment of hepatitis C virus. J. Rheumatol. 2005; 32: 1164-1167.
  8. Quartuccio L., De Marchi G., Fabris M., De Vita S. Development of type II mixed cryoglobulinemic syndrome after effective and persistent hepatitis C virus eradication. Rheumatology 2007; 46 (2): 367-368.
  9. Игнатова Т. М., Соловьева О. В., Чернова О. А., Кривошеев О. Г. Эффективное лечение ритуксимабом и противовирусными препаратами язвенно-некротического васкулита тяжелого течения и латентной HCV-инфекции. В кн.: Мухин Н. А. (ред.). Инновационные технологии и прогресс терапевтической клиники: Сборник статей. М.: Издательский дом "Русский врач"; 2008. 112-116.
  10. Landau D.-A., Saadoun D., Halfon P. et al. Relapse of hepatitis C virus-associated mixed cryoglobulinemia vasculitis in patients with sustained viral response. Arthr. Rheum. 2008; 58 (2): 604-611.
  11. Lin A., Kadam J. S., Bodenheimer H. C. et al. Concomitant diffuse large B-cell lymphoma and hepatocellular carcinoma in chronic hepatitis C virus liver disease: a study of two cases. J. Med. Virol. 2008; 80 (8): 1350-1353.
  12. Pham T. N. Q., Michalak T. I. Occult persistence and lymphotropism of hepatitis C virus infection. Wld J. Gastroenterol. 2008; 14 (18): 2789-2793.
  13. Giannini C., Petrarca A., Monti M. et al. Association between persistent lymphatic infection by hepatitis C virus after antiviral treatment and mixed cryoglobulinemia. Blood 2008; 111: 2943-2945.
  14. Welker M.-W., Zeuzem S. Occult hepatitis C: how convincing are the current data? Hepatology 2008; 49 (2): 665-675.
  15. Halfon P., Bourliere M., Ouzan D. et al. Occult hepatitis C virus infection revisited with ultrasensitive real-time PCR assay. J. Clin. Microbiol. 2008; 46: 2106-2108.
  16. De Vita S., Quartuccio L., Fabris M. Hepatitis C virus infection, mixed cryoglobulinemia and BlyS up-regulation: targeting the infectious trigger, autoimmune response, or both? Autoimmun. Rev. 2008; 8: 95-99.

Copyright (c) 2011 Ignatova T.M., Milovanova S.Y., Chernova O.A., Bayzhanova Z.Z., Ignatova T.M., Milovanova S.Y., Chernova O.A., Baizhanova Z.Z.

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This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 

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