B-cell lymphoma in a woman with chronic hepatitis C and mixed cryoglobulinemia of type 2


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Abstract

A report is presented of a rare case of B-cell non-Hodgkin"s lymphoma and severe exacerbation of cryoglobulinic vasculitis which developed in a female patient with chronic hepatitis C four years after achievement of a persistent virusological response to antivirus treatment. Causes of a specific course of the disease and development of the tumor in the absence of HCV in blood serum are discussed: latent HCV-infection in immune cells with persistent antigenic stimulation of B-lymphocytes, possibility of HCV-independent lymphoproliferation.

About the authors

Tat'yana Mikhaylovna Ignatova

Email: tmignatova@newmail.ru

Svetlana Yur'evna Milovanova

Ol'ga Alekseevna Chernova

Zhazira Zhambulatovna Bayzhanova

T M Ignatova

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

S Yu Milovanova

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

Institute of Rheumatology of the Russian Academy of Medical Sciences, Moscow

O A Chernova

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

Zh Zh Baizhanova

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

E.M. Tareev Clinic of Nephrology, Internal and Occupational Diseases of I.M. Sechenov Medical Academy, Moscow

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