Development of acute myeloid leukemia from donor cells after allogenic peripheral blood stem cell transplantation in a female patient with acute monoblastic leukemia

Abstract

Development of leukemia from donor cells is a rare complication of allogeneic blood stem cells (BSC). The paper describes a case of evolving acute myeloid leukemia of a graft in a patient with resistant acute monoblastic leukemia after related allogeneic peripheral BSC transplantation. The rarity of this complication, difficulties in providing evidence for the donor origin of a leukemic clone demonstrate a need for all-round careful dynamic assessment of the hematopoietic system after allogeneic transplantation, by applying the current cytogenetic (fluorescence in situ hybridization) and molecular (hypervariable genomic region amplification test using the polymerase chain reaction, hypervariable number of tandem repeats (VNTR), and short number of tandem repeats (STR)) techniques, which permits errors to be avoided in the assessment of a clinical situation and in the diagnosis of leukemia from donor cells. There is no developed policy for treatment of acute graft-versus-leukemia.

About the authors

Ol'ga Olegovna Shchegolevataya

Elena Nikolaevna Parovichnikova

I A Demidova

Valentin Grigor'evich Isaev

Andrey Nikolaevich Sokolov

Evgeniya Ivanovna Zhelnova

I V Alekseeva

V A Zherebtsova

T V Gaponova

Elena Vasil'evna Domracheva

Andrey Vital'evich Misyurin

L P Poreshina

I B Kaplanskaya

Elena Nikolaevna Ustinova

Elena Olegovna Gribanova

Valeriy Grigor'evich Savchenko

O O Schegolevataya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E N Parovichnikova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I A Demidova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V G Isaev

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

A N Sokolov

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E I Zhelnova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I V Alekseeva

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V A Zherebtsova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

T V Gaponova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E V Domracheva

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

A V Misyurin

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

L P Poreshina

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I B Kaplanskaya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E N Ustinova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E O Gribanova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V G Savchenko

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

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Copyright (c) 2011 Shchegolevataya O.O., Parovichnikova E.N., Demidova I.A., Isaev V.G., Sokolov A.N., Zhelnova E.I., Alekseeva I.V., Zherebtsova V.A., Gaponova T.V., Domracheva E.V., Misyurin A.V., Poreshina L.P., Kaplanskaya I.B., Ustinova E.N., Gribanova E.O., Savchenko V.G., Schegolevataya O.O., Parovichnikova E.N., Demidova I.A., Isaev V.G., Sokolov A.N., Zhelnova E.I., Alekseeva I.V., Zherebtsova V.A., Gaponova T.V., Domracheva E.V., Misyurin A.V., Poreshina L.P., Kaplanskaya I.B., Ustinova E.N., Gribanova E.O., Savchenko V.G.

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