Development of acute myeloid leukemia from donor cells after allogenic peripheral blood stem cell transplantation in a female patient with acute monoblastic leukemia


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Abstract

Development of leukemia from donor cells is a rare complication of allogeneic blood stem cells (BSC). The paper describes a case of evolving acute myeloid leukemia of a graft in a patient with resistant acute monoblastic leukemia after related allogeneic peripheral BSC transplantation. The rarity of this complication, difficulties in providing evidence for the donor origin of a leukemic clone demonstrate a need for all-round careful dynamic assessment of the hematopoietic system after allogeneic transplantation, by applying the current cytogenetic (fluorescence in situ hybridization) and molecular (hypervariable genomic region amplification test using the polymerase chain reaction, hypervariable number of tandem repeats (VNTR), and short number of tandem repeats (STR)) techniques, which permits errors to be avoided in the assessment of a clinical situation and in the diagnosis of leukemia from donor cells. There is no developed policy for treatment of acute graft-versus-leukemia.

About the authors

Ol'ga Olegovna Shchegolevataya

Elena Nikolaevna Parovichnikova

I A Demidova

Valentin Grigor'evich Isaev

Andrey Nikolaevich Sokolov

Evgeniya Ivanovna Zhelnova

I V Alekseeva

V A Zherebtsova

T V Gaponova

Elena Vasil'evna Domracheva

Andrey Vital'evich Misyurin

L P Poreshina

I B Kaplanskaya

Elena Nikolaevna Ustinova

Elena Olegovna Gribanova

Valeriy Grigor'evich Savchenko

O O Schegolevataya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E N Parovichnikova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I A Demidova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V G Isaev

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

A N Sokolov

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E I Zhelnova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I V Alekseeva

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V A Zherebtsova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

T V Gaponova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E V Domracheva

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

A V Misyurin

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

L P Poreshina

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

I B Kaplanskaya

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E N Ustinova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

E O Gribanova

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

V G Savchenko

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

Hematology Research Center, Russian Academy of Medical Sciences, Moscow

References

  1. Zander A. R., Bacher U., Finke J. Allogeneic stem cell transplantation in acute myeloid leukemia. Establishment of indications on the basis of individual risk stratification. Dtsch. Arztebl. Int. 2008; 105(39): 663-669.
  2. Воробьев А. И. Руководство по гематологии. М.: Ньюдиамед; 2002; т. 1: 175-182.
  3. Tallman M. S., Kim H. T., Paietta E. et al. Acute monocytic leukemia (French-American-British classification M5) does not have a worse prognosis than other subtypes of acute myeloid leukemia: A report from the Eastern Cooperative Oncology Group. J. Clin. Oncol. 2004; 22: 1276-1286.
  4. Jeong Hee Cho-Vega, Medeiros L. J., Prieto V. G. et al. Leukemia cutis. Am. J. Clin. Pathol. 2008; 129: 130-142.
  5. Mryzek K., Bloomfield C. D. Chromosome aberrations, gene mutations and expression changes, and prognosis in adult acute myeloid leukemia. Hematology; 2006. 169-177.
  6. Koreth J., Schlenk R., Kopecky K. J. et al. Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: Systematic review and meta-analysis of prospective clinical trials. J. A. M. A. 2009; 301(22): 2349-2361.
  7. Hertenstein B., Hambach L., Bacigalupo A. et al. Development of leukemia in donor cells after allogeneic stem cell transplantation - a survey of the European Group for Blood and Marrow Transplantation (EBMT). Haematologica 2005; 90: 969- 975.
  8. Cooley L. D., Sears D. A., Udden M. M. et al. Donor cell leukemia: Report of a case occurring 11 years after allogeneic bone marrow transplantation and review of the literature. Am. J. Hematol. 2000; 63: 46-53.
  9. Reichard K. K., Qian-Yun Zhang, Sanchez L. et al. Acute myeloid leukemia of donor origin after allogeneic bone marrow transplantation for precursor T-cell acute lymphoblastic leukemia: case report and review of the literature. Am. J. Hematol. 2006; 81: 178-185.
  10. Flynn C. M., Kaufman D. S. Donor cell leukemia: insight into cancer stem cells and the stem cell niche. Blood 2007; 109: 2688-2692.
  11. Spinelli O., Giussani U., Borleri G. et al. Need for an accurate molecular diagnosis to assess the donor origin of leukemia relapse after allogeneic stem cell transplantation. Haematologica 2000; 85: 1153-1157.
  12. Makoto Murata, Yuichi Ishikawa, Haruhiko Ohash et al. Donor cell leukemia after allogeneic peripheral blood stem cell transplantation: a case report and literature review. Int. J. Hematol. 2008; 88: 111-115.
  13. Hambach L., Eder M., Dammann E. et al. Donor cell-derived acute myeloid leukemia developing 14 month after matched unrelated bone marrow transplantation for chronic myeloid leukemia. Bone Marrow Transplant. 2001; 28: 705-707.
  14. Lawler1 M., Locasciulli A., Longoni D. et al. Leukaemic transformation of donor cells in a patient receiving a second allogeneic bone marrow transplant for severe aplastic anaemia. Bone Marrow Transplant. 2002; 29: 453-456.

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